Patents
US 12767700 B2: Compositions and methods comprising protease-activated therapeutic agents
- Granted
- 2026-10-20
- Filed
- 2022-05-05 application 18559180
- Type
- Utility · 15 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The disclosure relates to the engineering of collagen-binding modification of masked therapeutic agents comprising one or more tumor-associated protease cleavage sites. Upon exposure to tumor-associated proteases in the tumor microenvironment, the polypeptide is cleaved, which unmasks the therapeutic agent, reducing off-target side effects and toxicity associated with systemic administration. Accordingly, aspects of the disclosure relate to a polypeptide comprising a therapeutic agent linked to a masking agent through a linker, wherein the linker comprises one or more tumor-associated protease cleavage sites, and wherein the masking agent blocks the association of the therapeutic agent to its therapeutic target, and further wherein the polypeptide is operatively linked to a collagen binding domain or a tumor-targeting agent.
Source: PTBLXML, file of 2026-10-20 (ipgb20261020.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| THE UNIVERSITY OF CHICAGO 523 patents | US company or organization | Chicago, IL | University of Chicago College or university FUZZY medium confidence: same name (governing-board words and legal endings aside) and state UNIVERSITY OF CHICAGO Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-10-20 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jeffrey Hubbell | Chicago, IL | PTBLXML, file of 2026-10-20 | ||
| Jun Ishihara | Chicago, IL | 14 | PTBLXML, file of 2026-10-20 | |
| Juan Mendoza | Chicago, IL | PTBLXML, file of 2026-10-20 | ||
| Aslan Mansurov | Chicago, IL | 3 | PTBLXML, file of 2026-10-20 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K14/7155 | PTBLXML, file of 2026-10-20 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/1709 | PTBLXML, file of 2026-10-20 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PTBLXML, file of 2026-10-20 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.