Patents
US 12758653 B2: Lentiviral vectors in hematopoietic stem cells to treat X-linked chronic granulomatous disease
- Granted
- 2026-10-13
- Filed
- 2020-11-12 application 17775857
- Type
- Utility · 12 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Described herein is a lentiviral vector (LV) for the treatment of X-linked chronic granulomatous disease (X-CGD). The vector comprises an expression cassette comprising a nucleic acid construct comprising a CYBB promoter or effective fragment thereof, and a nucleic acid that encodes gp91phox operably linked to the CYBB promoter or promoter fragment thereof.
Source: PTBLXML, file of 2026-10-13 (ipgb20261013.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 8,781 patents | US company or organization | Oakland, CA | REGENTS OF THE UNIVERSITY OF CALIFORNIA State business registration FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-10-13 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Donald B. Kohn | Tarzana, CA | 10 | PTBLXML, file of 2026-10-13 | |
| Ryan L. Wong | Los Angeles, CA | PTBLXML, file of 2026-10-13 | ||
| Roger Paul Hollis | Los Angeles, CA | 8 | PTBLXML, file of 2026-10-13 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K48/005 | PTBLXML, file of 2026-10-13 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P37/00 | PTBLXML, file of 2026-10-13 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/0036 | PTBLXML, file of 2026-10-13 |
| C12Y | Enzymes | C12Y106/03001 | PTBLXML, file of 2026-10-13 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.