Patents
US 12758622 B2: Chitinase administration to the airway to treat inflammation and age-related pulmonary fibrosis
- Granted
- 2026-10-13
- Filed
- 2018-04-11 application 16604979
- Type
- Utility · 6 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Herein is demonstrated that expression of the enzyme chitinase in the lungs of animals is protective against adverse chitin-mediated inflammation and that with impaired chitinase expression, various inflammatory pathways are enhanced, contributing to conditions such as fibrotic lung disease. Further, it is shown that the prevention and treatment of pulmonary fibrosis and other improvements to lung health are achieved by administration of chitinase to the lungs. Additionally, methods of assessing chitinase activity in the lungs provide a novel diagnostic measure of lung health.
Source: PTBLXML, file of 2026-10-13 (ipgb20261013.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 8,781 patents | US company or organization | Oakland, CA | REGENTS OF THE UNIVERSITY OF CALIFORNIA State business registration FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-10-13 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Richard Locksley | San Francisco, CA | PTBLXML, file of 2026-10-13 | ||
| Steven Van Dyken | San Francisco, CA | PTBLXML, file of 2026-10-13 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/47 | PTBLXML, file of 2026-10-13 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P11/00 | PTBLXML, file of 2026-10-13 |
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/34 | PTBLXML, file of 2026-10-13 |
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N33/6893 | PTBLXML, file of 2026-10-13 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/2442 | PTBLXML, file of 2026-10-13 |
| C12Y | Enzymes | C12Y302/01014 | PTBLXML, file of 2026-10-13 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.