Patents
US 12753402 B2: Orthogonal ubiquitin transfer as a method to identify cellular substrates of E3 ubiquitin ligases
- Granted
- 2026-10-06
- Filed
- 2019-12-19 application 16721345
- Type
- Utility · 19 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed herein are compounds, compositions, and methods for identifying substrates of E3 ubiquitin ligases. The proteins, vectors, compositions, and may be utilized in methods for orthogonal ubiquitin transfer (OUT) between variant components of the ubiquitin cascade such as a variant ubiquitin (UB), a variant ubiquitin activating enzyme (E1), a variant ubiquitin-conjugating enzyme (E2), and a variant ubiquitin ligase (E3), which may include a variant HECT type, U-box type, RBR type, and/or Ring type E3 ligase. The variant components of the ubiquitin cascade typically include one or more mutations relative to their wild-type counterparts, such as amino acid substitutions, such that the variant components interact specifically and orthogonally with each of their variant components and do not interact with the wild-type counterpart of their variant components.
Source: PTBLXML, file of 2026-10-06 (ipgb20261006.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Northwestern University 2,267 patents | US company or organization | Evanston, IL | Northwestern University College or university EXACT high confidence: identical full name and state NORTHWESTERN UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-10-06 |
| Georgia State University Research Foundation 149 patents | US company or organization | Atlanta, GA | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION INC Nonprofit EXACT high confidence: identical full name and state GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION Federal lobbying client FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-10-06 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jun Yin | Atlanta, GA | 10 | PTBLXML, file of 2026-10-06 | |
| Hiroaki Kiyokawa | Chicago, IL | PTBLXML, file of 2026-10-06 | ||
| Yiyang Wang | Atlanta, GA | PTBLXML, file of 2026-10-06 | ||
| Karan Bhuripanyo | Atlanta, GA | PTBLXML, file of 2026-10-06 | ||
| Bo Zhao | Atlanta, GA | PTBLXML, file of 2026-10-06 | ||
| Xianpeng Liu | Evanston, IL | PTBLXML, file of 2026-10-06 | ||
| Li Zhou | Atlanta, GA | PTBLXML, file of 2026-10-06 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/1055 | PTBLXML, file of 2026-10-06 |
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N33/6845 | PTBLXML, file of 2026-10-06 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.