Patents
US 12752014 B2: Disruption of CD28-sialoside ligand complexes to enhance T cell activation
- Granted
- 2026-10-06
- Filed
- 2021-07-21 application 18041715
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention provides methods for enhancing T cell activation and expansion, and methods for stimulating a T cell immune response in a subject. The methods of the invention involve the use of a targeting agent-enzyme conjugate that contains (a) a targeting moiety that specifically binds a cell surface molecule on T cells, and (b) a sialidase or enzymatically active fragment thereof. Also provided in the invention are targeting agent-enzyme conjugates that can be used in the therapeutic methods, including antibody conjugates that are formed of a sialidase and a T cell targeting antibody (e.g., an anti-PD1 antibody).
Source: PTBLXML, file of 2026-10-06 (ipgb20261006.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Scripps Research Institute 569 patents | US company or organization | La Jolla, CA | The Scripps Research Institute State business registration EXACT high confidence: identical full name and state SCRIPPS RESEARCH INSTITUTE Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-10-06 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| James C. Paulson | Del Mar, CA | 7 | PTBLXML, file of 2026-10-06 | |
| Landon J. Edgar | San Diego, CA | PTBLXML, file of 2026-10-06 | ||
| Andrew J. Thompson | San Diego, CA | PTBLXML, file of 2026-10-06 | ||
| Chika Kikuchi | San Diego, CA | PTBLXML, file of 2026-10-06 | ||
| Brett Garabedian | Del Mar, CA | PTBLXML, file of 2026-10-06 | ||
| Xiaoshuang Wang | San Diego, CA | PTBLXML, file of 2026-10-06 | ||
| Eleanor Bashian | Laguna Niguel, CA | PTBLXML, file of 2026-10-06 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K47/6815 | PTBLXML, file of 2026-10-06 |
| C07K | Peptides | C07K16/2818 | PTBLXML, file of 2026-10-06 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/2402 | PTBLXML, file of 2026-10-06 |
| C12Y | Enzymes | C12Y302/01018 | PTBLXML, file of 2026-10-06 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.