Patents
US 12748111 B2: Methods for detection of pathogenic antiphospholipid antibodies and for identification of inhibitors
- Granted
- 2026-09-29
- Filed
- 2020-12-09 application 17789823
- Type
- Utility · 9 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention provides methods for detecting whether a subject suffers from an autoimmune disease, such as, for example, antiphospholipid syndrome (APS), by detecting antiphospholipid antibodies (aPL) in a sample using a novel target, the lysobisphosphatidic acid (LBPA) bound to the endothelial protein C receptor (EPCR) or an LBPA-binding fragment thereof. Furthermore, methods for identifying an inhibitor of endothelial protein C receptor (EPCR) function in autoimmune disease, preferably without a side effect on EPCR regulatory function in coagulation, and a method for producing a pharmaceutical composition comprising the steps of identifying a potential inhibitor, and suitably formulating said potential inhibitor into a pharmaceutical composition are provided. Methods for treating and/or preventing an autoimmune disease, such as, for example, antiphospholipid syndrome, in a subject are also provided.
Source: PTBLXML, file of 2026-09-29 (ipgb20260929.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ 24 patents | Foreign company or organization | Mainz, DE | PTBLXML, file of 2026-09-29 | |
| THE SCRIPPS RESEARCH INSTITUTE 569 patents | US company or organization | La Jolla, CA | The Scripps Research Institute State business registration EXACT high confidence: identical full name and state SCRIPPS RESEARCH INSTITUTE Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-09-29 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Wolfram Ruf | San Diego, CA | 3 | PTBLXML, file of 2026-09-29 | |
| Nadine Müller-Calleja | Mainz, DE | PTBLXML, file of 2026-09-29 | ||
| Karl Lackner | Mainz, DE | PTBLXML, file of 2026-09-29 | ||
| Luc Teyton | La Jolla, CA | 8 | PTBLXML, file of 2026-09-29 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N33/564 | PTBLXML, file of 2026-09-29 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.