Patents
US 12747296 B2: Anti-CCR8 antibodies for treating cancer
- Granted
- 2026-09-29
- Filed
- 2021-03-22 application 17914257
- Type
- Utility · 36 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
This disclosure provides isolated antibodies, for example, monoclonal antibodies, that specifically bind to the C-C Motif Chemokine Receptor 8 (CCR8) expressed on the surface of a cell and mediate depletion of the CCR8-expressing cell by anti-body-dependent cellular cytotoxicity (ADCC). The disclosure provides methods for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-CCR8 antibody as monotherapy or in combination with an anti-cancer agent such as an immune checkpoint inhibitor, for example, an anti-PD-1 or anti-PD-L1 antibody.
Source: PTBLXML, file of 2026-09-29 (ipgb20260929.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| BRISTOL-MYERS SQUIBB COMPANY 1,812 patents | US company or organization | Princeton, NJ | BRISTOL MYERS SQUIBB CO SEC filer FUZZY low confidence: same name (legal endings aside), one of each nationally | PTBLXML, file of 2026-09-29 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Ruth Yin-Zong Lan | Fremont, CA | PTBLXML, file of 2026-09-29 | ||
| Olufemi A. Adelakun | Kendall Park, NJ | 3 | PTBLXML, file of 2026-09-29 | |
| Ishita Barman | Millbrae, CA | PTBLXML, file of 2026-09-29 | ||
| Joseph Richard Campbell | Stanford, CA | PTBLXML, file of 2026-09-29 | ||
| SJ Jian Zhe Diong | San Mateo, CA | PTBLXML, file of 2026-09-29 | ||
| Felix Findeisen | San Francisco, CA | PTBLXML, file of 2026-09-29 | ||
| Danielle M. Greenawalt | Philadelphia, PA | 3 | PTBLXML, file of 2026-09-29 | |
| Renu Jain | Redwood City, CA | PTBLXML, file of 2026-09-29 | ||
| Amy D. Jhatakia | Freemont, CA | 4 | PTBLXML, file of 2026-09-29 | |
| John K. Lee | Alameda, CA | PTBLXML, file of 2026-09-29 | ||
| Peter Sung Keun Lee | Millbrae, CA | 3 | PTBLXML, file of 2026-09-29 | |
| Linda Liang | Mountain View, CA | 22 | PTBLXML, file of 2026-09-29 | |
| Kai Lu | Foster City, CA | PTBLXML, file of 2026-09-29 | ||
| Bryan McDonald | San Diego, CA | PTBLXML, file of 2026-09-29 | ||
| Paul Blaine Mesko | Redwood City, CA | 2 | PTBLXML, file of 2026-09-29 | |
| Arvind Rajpal | San Francisco, CA | 46 | PTBLXML, file of 2026-09-29 | |
| Sharmila Sambanthamoorthy | Belmont, CA | PTBLXML, file of 2026-09-29 | ||
| Mark J. Selby | San Francisco, CA | 66 | PTBLXML, file of 2026-09-29 | |
| Nathan O. Siemers | Pacific Grove, CA | PTBLXML, file of 2026-09-29 | ||
| Pavel Strop | San Mateo, CA | 31 | PTBLXML, file of 2026-09-29 | |
| Gaby A. Terracina | Metuchen, NJ | 2 | PTBLXML, file of 2026-09-29 | |
| Xi-Tao Wang | Princeton, NJ | 25 | PTBLXML, file of 2026-09-29 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K16/2866 | PTBLXML, file of 2026-09-29 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PTBLXML, file of 2026-09-29 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K2039/505 | PTBLXML, file of 2026-09-29 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.