Patents
US 12742179 B2: Methods of treating rheumatoid arthritis using RNA-guided genome editing of HLA gene
- Granted
- 2026-09-22
- Filed
- 2024-03-14 application 18605149
- Type
- Utility · 10 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Methods of preventing or treating rheumatoid arthritis (RA) in a subject by introducing the DRB1*04:01K71E mutation that is resistant to RA. The resistant allele is introduced into the subject having or at risk of developing RA, using a HLA CRISPR/Cas9 vector that targets codon 71 in the HLA allele DRB1*04:01, introducing a single A to G point mutation in codon 71 by homology directed repair to alter the lysine at position 71 of the expressed protein to glutamic acid. This modified allele is affected in the subject's hematopoietic stem cells, which are then expanded and transplanted back into the patient. This microgene therapy confers RA-resistance via an autologous transplant. The invention includes isolated nucleic acids, vectors, recombinant viruses, cells, and pharmaceutical compositions to modify the HLA DRB1*04:01 allele.
Source: PTBLXML, file of 2026-09-22 (ipgb20260922.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE 771 patents | US company or organization | Denver, CO | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE CORP. State business registration FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-09-22 |
| NATIONAL JEWISH HEALTH 82 patents | US company or organization | Denver, CO | NATIONAL JEWISH HEALTH Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-09-22 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Brian Freed | Aurora, CO | 6 | PTBLXML, file of 2026-09-22 | |
| Kirsten Anderson | Denver, CO | 2 | PTBLXML, file of 2026-09-22 | |
| Christina Roark | Englewood, CO | 4 | PTBLXML, file of 2026-09-22 | |
| Jennifer Matsuda | Denver, CO | 2 | PTBLXML, file of 2026-09-22 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/85 | PTBLXML, file of 2026-09-22 |
| A01K | Animal husbandry; aviculture; apiculture; pisciculture; fishing; rearing or breeding animals, not otherwise provided for; new breeds of animals | A01K67/0275 | PTBLXML, file of 2026-09-22 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K35/28 | PTBLXML, file of 2026-09-22 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.