Patents
US 12740989 B2: Notch signaling inhibitors for treating obesity and metabolic disorders
- Granted
- 2026-09-22
- Filed
- 2021-07-23 application 18017384
- Type
- Utility · 18 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided is the use of Notch signaling inhibitors such as γ-secretase inhibitors (GSIs), which increase expression of uncoupling protein-1 (UCP-1), to selectively increase browning of white adipose tissue, for example, in the treatment of obesity and metabolic disorders such as type 2 diabetes mellitus (T2DM), fatty liver disease, atherosclerosis, and others, including comorbidities thereof.
Source: PTBLXML, file of 2026-09-22 (ipgb20260922.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Purdue Research Foundation 2,151 patents | US company or organization | West Lafayette, IN | PURDUE RESEARCH FOUNDATION Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-09-22 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Meng Deng | West Lafayette, IN | 14 | PTBLXML, file of 2026-09-22 | |
| Di Huang | Malden, MA | PTBLXML, file of 2026-09-22 | ||
| Shihuan Kuang | West Lafayette, IN | 4 | PTBLXML, file of 2026-09-22 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/55 | PTBLXML, file of 2026-09-22 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P3/08 | PTBLXML, file of 2026-09-22 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.