Patents
US 12714740 B2: Compositions comprising a tweak ligand and methods of using same
- Granted
- 2026-08-25
- Filed
- 2020-04-29 application 17604557
- Type
- Utility · 12 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The instant disclosure relates to nanoparticle compositions that may be used for the targeting of certain cells or tissues. The nanoparticles may take a variety of different forms, including non-viral, viral, and lipid nanoparticles, and may utilize a TNF receptor superfamily member 12A (“TWEAKR”) binding region of the TWEAK protein to target a nanoparticle to tissues expressing TWEAKR. The compositions may further comprise a suicide gene optionally under the control of a tissue specific promoter. In further aspects, methods of treating an individual using the disclosed nanoparticle compositions are described.
Source: PTBLXML, file of 2026-08-25 (ipgb20260825.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Children's Hospital Medical Center 292 patents | US company or organization | Cincinnati, OH | Children's Hospital Medical Center State business registration EXACT high confidence: identical full name and state | PTBLXML, file of 2026-08-25 |
| UNIVERSITY OF CINCINNATI 317 patents | US company or organization | Cincinnati, OH | UNIVERSITY OF CINCINNATI Federal lobbying client EXACT high confidence: identical full name and state | PTBLXML, file of 2026-08-25 |
| University of Kentucky Research Foundation 446 patents | US company or organization | Lexington, KY | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-08-25 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| David Yurek | Lexington, KY | PTBLXML, file of 2026-08-25 | ||
| Kim B. Seroogy | Loveland, OH | PTBLXML, file of 2026-08-25 | ||
| Assem Ziady | Cincinnati, OH | 6 | PTBLXML, file of 2026-08-25 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/191 | PTBLXML, file of 2026-08-25 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-01-13 | Assignment Assignment of assignor's interest | ZIADY, ASSEM signed 2020-03-20 | CHILDREN'S HOSPITAL MEDICAL CENTER CINCINNATI, OH | 58643/217 | PASDL, file of 2026-08-13 |
| 2022-01-13 | Assignment Assignment of assignor's interest | SEROOGY, KIM signed 2021-07-26 | UNIVERSITY OF CINCINNATI CINCINNATI, OH | 58643/131 | PASDL, file of 2026-08-13 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.