Patents
US 12708609 B2: Methods and compositions for treating inflammation
- Granted
- 2026-08-18
- Filed
- 2023-11-22 application 18517596
- Type
- Utility · 6 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed herein are methods and compositions for treating neutrophil-mediated inflammation by targeting, in any combination, the pro-inflammatory MRP2/HXA3 pathway and/or the anti-inflammatory P-gp/endocannabinoid pathway and/or the anti-inflammatory MRP 1/L-AMEND pathway, comprising administering to the subject a therapeutically effective amount of (a) one or more first compound that inhibits the activity and/or level of one or more of multidrug resistance protein 2 (MRP2) and hepoxilin A3 (HXA3) synthase, and/or (b) one or more second compound that increases the level and/or activity of one or more N-acylethanolamines (NAEs), and/or (c) one or more third compound that increases the level and/or activity of multidrug resistance protein 1 (MRP1), wherein the therapeutic amount of the first, second, and third compounds reduces migration of neutrophils into the target tissue.
Source: PTBLXML, file of 2026-08-18 (ipgb20260818.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| UNIVERSITY OF BATH 32 patents | Foreign company or organization | Bath, GB | PTBLXML, file of 2026-08-18 | |
| UNIVERSITY OF MASSACHUSETTS 1,152 patents | US company or organization | Boston, MA | UNIVERSITY OF MASSACHUSETTS Federal lobbying client EXACT high confidence: identical full name and state | PTBLXML, file of 2026-08-18 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Randall Mrsny | Los Altos Hills, CA | PTBLXML, file of 2026-08-18 | ||
| Beth McCormick | Haverhill, MA | 4 | PTBLXML, file of 2026-08-18 | |
| Roland Ellwood Dolle | Ashland, MA | PTBLXML, file of 2026-08-18 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/195 | PTBLXML, file of 2026-08-18 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-03-06 | Assignment Assignment of assignor's interest | BACAINN BIOTHERAPEUTICS LTD signed 2019-04-30 | UNIVERSITY OF MASSACHUSETTS BOSTON, MA | 66662/761 | PASDL, file of 2026-08-13 |
| 2024-03-06 | Assignment Assignment of assignor's interest | BACAINN BIOTHERAPEUTICS LTD. signed 2019-10-01 | UNIVERSITY OF BATH BATH | 66662/368 | PASDL, file of 2026-08-13 |
| 2024-02-26 | Assignment Assignment of assignor's interest | MCCORMICK, BETH A signed 2019-03-20 | UNIVERSITY OF MASSACHUSETTS BOSTON, MA | 66560/808 | PASDL, file of 2026-08-13 |
| 2024-02-26 | Assignment Assignment of assignor's interest | MRSNY, RANDALL signed 2019-04-27 | UNIVERSITY OF BATH BATH | 66560/704 | PASDL, file of 2026-08-13 |
| 2024-02-26 | Assignment Assignment of assignor's interest | DOLLE, ROLAND ELLWOOD signed 2017-07-21 | BACAINN BIOTHERAPEUTICS, LTD GEORGE TOWN | 66560/230 | PASDL, file of 2026-08-13 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.