Patents
US 12703863 B2: RNA G-quadruplex structure in pre-miRNA-1229 as a therapeutic target for Alzheimer's disease and various cancers
- Granted
- 2026-08-11
- Filed
- 2021-04-15 application 17301835
- Type
- Utility · 2 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided is an agent that binds to a wild type or variant pre-miRNA-1229 comprising a G-quadruplex (GQ) structure, wherein binding of the agent to the wild type or variant pre-miRNA-1229 stabilizes the GQ structure of the wild type or variant pre-miRNA-1229. In some embodiments, the variant is rs2291418. Provided is a method of treating a disease in a subject, comprising: administering a therapeutically effective amount of the agent to the subject. In some embodiments, the disease is Alzheimer's disease, cancer or coronary artery calcification.
Source: PTBLXML, file of 2026-08-11 (ipgb20260811.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| DUQUESNE UNIVERSITY OF THE HOLY SPIRIT 70 patents | US company or organization | Pittsburgh, PA | Duquesne University College or university EXACT high confidence: through the nonprofit with the college's EIN (identical full name and state) DUQUESNE UNIVERSITY OF THE HOLY SPIRIT Federal lobbying client EXACT high confidence: identical full name and state DUQUESNE UNIVERSITY OF THE HOLY SPIRIT Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-08-11 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Mihaela Rita Mihailescu | Pittsburgh, PA | PTBLXML, file of 2026-08-11 | ||
| Joshua A. Imperatore | Canonsburg, PA | PTBLXML, file of 2026-08-11 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/113 | PTBLXML, file of 2026-08-11 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-12-20 | Assignment Assignment of assignor's interest | MIHAILESCU, MIHAELA RITA signed 2022-12-14 IMPERATORE, JOSHUA A. signed 2022-12-14 | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT PITTSBURGH, PA | 62158/488 | PASDL, file of 2026-08-13 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.