Patents
US 12703851 B2: Cell culture methods
- Granted
- 2026-08-11
- Filed
- 2022-02-14 application 17671029
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A method of cell culture includes (i) culturing cells in a cell culture medium, and (ii) maintaining at least one metabolite below an inhibitory concentration in the cell culture medium for the at least one metabolite, wherein the at least one metabolite is aconitic acid (AA), leucinic acid (HICA), cytidine monophosphate (CMP), methylsuccinic acid (MSA), trigonelline (TRI), N-acetylputrescinium (NAP), or a combination thereof, and wherein the enzyme comprises ADH5, BCAT1, CAT, GOT1, HADHB, HOGA1, SLC35A1, or a combination thereof.
Source: PTBLXML, file of 2026-08-11 (ipgb20260811.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| THE UNIVERSITY OF MASSACHUSETTS 1,152 patents | US company or organization | Boston, MA | UNIVERSITY OF MASSACHUSETTS Federal lobbying client EXACT high confidence: identical full name and state | PTBLXML, file of 2026-08-11 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Seongkyu Yoon | Lowell, MA | 2 | PTBLXML, file of 2026-08-11 | |
| Bingyu Kuang | Worcester, MA | PTBLXML, file of 2026-08-11 | ||
| Duc Hoang | Burnsville, MN | PTBLXML, file of 2026-08-11 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N5/0025 | PTBLXML, file of 2026-08-11 |
| G01J | Measurement of intensity, velocity, spectral content, polarisation, phase or pulse characteristics of infrared, visible or ultraviolet light; colorimetry; radiation pyrometry | G01J3/44 | PTBLXML, file of 2026-08-11 |
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N30/7206 | PTBLXML, file of 2026-08-11 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.