Patents
US 12702654 B2: Compositions and methods for treating homocystinuria and other conditions using polyamines
- Granted
- 2026-08-11
- Filed
- 2023-05-05 application 18312772
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Embodiments of the instant disclosure relate to novel compositions and methods for treating a subject having genetic homocystinuria (HCU or other form of genetic homocystinuria). In some embodiments, compositions and methods disclosed herein concern improving efficacy of standard treatments (e.g. trimethylglycine) to reduce dietary compliance requirements and improve outcomes. In accordance with these embodiments, a subject having or suspected of developing classical cystathionine beta-synthase deficient homocystinuria (HCU) or other genetic form of homocystinuria can be treated with a polyamine or diamine or a precursor thereof or a combination thereof for example, in combination with trimethylglycine (e.g. betaine) or other genetic homocystinuria treatment. In other embodiments, a subject having or suspected of developing HCU or other genetic homocystinuria can also be treated with formate or formate derivative, or zinc and/or zinc-containing agent or other standard treatment in combination with a polyamine composition to treat HCU or RD or other form of genetic homocystinuria in the subject.
Source: PTBLXML, file of 2026-08-11 (ipgb20260811.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE 771 patents | US company or organization | Denver, CO | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE CORP. State business registration FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-08-11 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Kenneth N. Maclean | Lakewood, CO | 2 | PTBLXML, file of 2026-08-11 | |
| Hua Jiang | Centennial, CO | 74 | PTBLXML, file of 2026-08-11 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/205 | PTBLXML, file of 2026-08-11 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P7/02 | PTBLXML, file of 2026-08-11 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.