Patents
US 12698497 B2: Stability and activity of enzymes by immobilization
- Granted
- 2026-08-04
- Filed
- 2021-11-15 application 18036678
- Type
- Utility · 10 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A polymer brush composed of statistical copolymers of hydrophilic and hydrophobic monomers for enzyme immobilization. The heterogeneous polymer brushes stabilized four different lipases against high temperatures. Notably, the statistical copolymers stabilized the four lipases to a greater extent than a homopolymer brush. Additionally, in the case of Rhizomucor miehei lipase, statistical copolymers stabilized the enzyme to a greater extent than homopolymers of either hydrophilic or hydrophobic monomers. The resulting increase in high-temperature stability enabled significant improvements in catalytic rates by operating reactions at elevated temperatures, which is desirable for enzyme catalysis and sensing applications. Additionally, stabilization against elevated temperatures implies stabilization against non-aqueous solvents, which is of critical importance to numerous applications of biocatalysts.
Source: PTBLXML, file of 2026-08-04 (ipgb20260804.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Regents of the University of Colorado 307 patents | US company or organization | Denver, CO | THE REGENTS OF THE UNIVERSITY OF COLORADO Federal lobbying client EXACT high confidence: identical full name and state REGENTS OF THE UNIVERSITY OF COLORADO Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-08-04 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| James S. Weltz | Denver, CO | PTBLXML, file of 2026-08-04 | ||
| Joel L. Kaar | Lafayette, CO | PTBLXML, file of 2026-08-04 | ||
| Daniel K. Schwartz | Boulder, CO | 5 | PTBLXML, file of 2026-08-04 | |
| Hector Sanchez-Moran | Boulder, CO | PTBLXML, file of 2026-08-04 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N11/08 | PTBLXML, file of 2026-08-04 |
| B01J | Chemical or physical processes, e.g. catalysis or colloid chemistry; their relevant apparatus | B01J13/14 | PTBLXML, file of 2026-08-04 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.