Patents
US 12698259 B2: Transcriptional enhanced associate domain (TEAD) transcription factor inhibitors and uses thereof
- Granted
- 2026-08-04
- Filed
- 2019-10-15 application 17285791
- Type
- Utility · 13 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, compositions, and mixtures thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers, such as carcinoma, sarcoma, lung cancer, thyroid cancer, skin cancer, ovarian cancer, colorectal cancer, prostate cancer, pancreatic cancer, esophageal cancer, liver cancer, breast cancer)) in a subject. Provided are methods of inhibiting a TEAD transcription factors (e.g., TEAD1, TEAD2, TEAD3, TEAD4) in a subject.
Source: PTBLXML, file of 2026-08-04 (ipgb20260804.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Dana-Farber Cancer Institute, Inc. 892 patents | US company or organization | Boston, MA | DANA-FARBER CANCER INSTITUTE, INC. Federal lobbying client EXACT high confidence: identical full name and state DANA-FARBER CANCER INSTITUTE Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-08-04 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Nathanael S. Gray | Boston, MA | 178 | PTBLXML, file of 2026-08-04 | |
| Tinghu Zhang | Brookline, MA | 62 | PTBLXML, file of 2026-08-04 | |
| Yao Liu | Brookline, MA | 17 | PTBLXML, file of 2026-08-04 | |
| Mengyang Fan | Allston, MA | PTBLXML, file of 2026-08-04 | ||
| Yang Gao | Boston, MA | PTBLXML, file of 2026-08-04 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D205/04 | PTBLXML, file of 2026-08-04 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K45/06 | PTBLXML, file of 2026-08-04 |
| C07C | Acyclic or carbocyclic compounds | C07C233/44 | PTBLXML, file of 2026-08-04 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2026-06-04 | Assignment Assignment of assignor's interest | GRAY, NATHANAEL S. signed 2020-06-10 ZHANG, TINGHU signed 2020-07-16 LIU, YAO signed 2020-06-07 FAN, MENGYANG signed 2020-06-07 GAO, YANG signed 2020-09-22 | DANA-FARBER CANCER INSTITUTE, INC. BOSTON, MA | 74856/941 | PASDL, file of 2026-08-13 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.