Patents
US 12697401 B2: Thrombus imaging aptamers and methods of using same
- Granted
- 2026-08-04
- Filed
- 2022-12-21 application 18086378
- Type
- Utility · 17 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.
Source: PTBLXML, file of 2026-08-04 (ipgb20260804.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Duke University 1,375 patents | US company or organization | Durham, NC | Duke University College or university EXACT high confidence: identical full name and state DUKE UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-08-04 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Bruce A. Sullenger | Durham, NC | 37 | PTBLXML, file of 2026-08-04 | |
| Kady-Ann C. Steen-Burrell | Durham, NC | 3 | PTBLXML, file of 2026-08-04 | |
| Bethany Powell Gray | Durham, NC | 3 | PTBLXML, file of 2026-08-04 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K49/0002 | PTBLXML, file of 2026-08-04 |
| C07H | Sugars; derivatives thereof; nucleosides; nucleotides; nucleic acids | C07H21/02 | PTBLXML, file of 2026-08-04 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/115 | PTBLXML, file of 2026-08-04 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.