Patents
US 12692496 B2: Compositions and methods for modulating RPGR expression
- Granted
- 2026-07-28
- Filed
- 2021-03-04 application 17909148
- Type
- Utility · 17 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Aspects of the disclosure relate to compositions and methods for modulating expression of certain RPGR retinitis pigmentosa GTPase regulator (RPGR) proteins in a cell or subject. In some embodiments the disclosure provides expression vectors encoding one or more RPGR proteins and/or one or more inhibitory nucleic acids that target certain isoforms of RPGR, for example RPGRCONST. In some aspects, the disclosure relates to methods of treating retinitis pigmentosa (RP) in a subject by administering compositions that modulate RPGR expression or activity.
Source: PTBLXML, file of 2026-07-28 (ipgb20260728.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| University of Massachusetts 1,152 patents | US company or organization | Westborough, MA | UNIVERSITY OF MASSACHUSETTS Federal lobbying client EXACT high confidence: identical full name and state | PTBLXML, file of 2026-07-28 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Hemant Khanna | Worcester, MA | 8 | PTBLXML, file of 2026-07-28 | |
| Laura Moreno Leon | Worcester, MA | PTBLXML, file of 2026-07-28 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/113 | PTBLXML, file of 2026-07-28 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P27/02 | PTBLXML, file of 2026-07-28 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-12-01 | Assignment Assignment of assignor's interest | KHANNA, HEMANT signed 2021-06-09 MORENO-LEON, LAURA signed 2021-03-04 | UNIVERSITY OF MASSACHUSETTS BOSTON, MA | 61937/340 | PASDL, file of 2026-08-13 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.