Patents
US 12691303 B2: Techniques for detecting in real-time proton beam therapy three dimensional dose delivered
- Granted
- 2026-07-28
- Filed
- 2024-07-05 application 18764627
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Techniques for detecting real-time proton beam dose include retrieving conversion data for converting proton dose to acoustic pressure based on medical imagery. 3D medical imagery is retrieved of a first region of interest (ROI) inside a first subject. A real-time signal indicates ultrasound pressure at a 2D ultrasound array disposed outside and in contact with the first subject close to the first ROI. Real-time 3D dose delivered in the first ROI is determined by inputting the real-time signal into a dose detection module that includes a neural network. The neural network is trained on multiple instances of a training set. Each instance includes: simulated proton dose delivered to a similar ROI inside a second subject; simulated pressure generation from that simulated dose based on the conversion data and a similar 3D medical image; and simulated acoustic transmission from the similar ROI to a similar two-dimensional ultrasound transducer array similarly disposed.
Source: PTBLXML, file of 2026-07-28 (ipgb20260728.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| University of Maryland 180 patents | US company or organization | Baltimore, MD | UNIVERSITY OF MARYLAND Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-07-28 |
| Duke University 1,375 patents | US company or organization | Durham, NC | Duke University College or university EXACT high confidence: identical full name and state DUKE UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-07-28 |
| Regents of the University of California 8,781 patents | US company or organization | Oakland, CA | REGENTS OF THE UNIVERSITY OF CALIFORNIA State business registration FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-07-28 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Lei Ren | Clarksville, MD | PTBLXML, file of 2026-07-28 | ||
| Zhuoran Jiang | Durham, NC | PTBLXML, file of 2026-07-28 | ||
| Leshan Sun | Irvine, CA | PTBLXML, file of 2026-07-28 | ||
| Liangzhong Xiang | Irvine, CA | PTBLXML, file of 2026-07-28 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61N | Electrotherapy; magnetotherapy; radiation therapy; ultrasound therapy | A61N5/1049 | PTBLXML, file of 2026-07-28 |
| G16H | Healthcare informatics, i.e. information and communication technology [ict] specially adapted for the handling or processing of medical or healthcare data | G16H20/40 | PTBLXML, file of 2026-07-28 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.