Patents
US 12686868 B2: Methods and compositions for rejuvenating CNS glial populations by suppresion of transcription factors
- Granted
- 2026-07-21
- Filed
- 2022-10-19 application 18047749
- Type
- Utility · 12 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Methods of inducing rejuvenation in a population of adult glial progenitor cells, and methods of treating a subject having a myelin deficiency are disclosed in this patent application. The method of inducing rejuvenation in a population of adult glial progenitor cells may comprise administering, to the population of adult glial progenitor cells, an effective amount of an agent that suppresses one or more transcription factors selected from the group consisting of (i) zinc finger protein 274 (ZNF274), (ii) Myc-associated factor X (MAX), (iii) E2F transcription factor 6 (E2F6), (iv) zinc finger protein Aiolos (IKZF3), and (v) signal transducer and activator of transcription 3 (STAT3).
Source: PTBLXML, file of 2026-07-21 (ipgb20260721.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| University of Rochester 570 patents | US company or organization | Rochester, NY | UNIVERSITY OF ROCHESTER State business registration EXACT high confidence: identical full name and state University of Rochester College or university EXACT high confidence: identical full name and state UNIVERSITY OF ROCHESTER Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-07-21 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Steven A. Goldman | Webster, NY | 31 | PTBLXML, file of 2026-07-21 | |
| John N. Mariani | Rochester, NY | PTBLXML, file of 2026-07-21 | ||
| Abdellatif Benraiss | Rochester, NY | PTBLXML, file of 2026-07-21 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/113 | PTBLXML, file of 2026-07-21 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/1709 | PTBLXML, file of 2026-07-21 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P25/00 | PTBLXML, file of 2026-07-21 |
| C12Y | Enzymes | C12Y305/01098 | PTBLXML, file of 2026-07-21 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-10-28 | Assignment Assignment of assignor's interest | GOLDMAN, STEVEN A. signed 2022-10-21 MARIANI, JOHN N. signed 2022-10-21 BENRAISS, ABDELLATIF signed 2022-10-21 | UNIVERSITY OF ROCHESTER ROCHESTER, NY | 61573/730 | PASDL, file of 2026-08-13 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.