Patents
US 12686862 B2: CRISPR enzymes and systems
- Granted
- 2026-07-21
- Filed
- 2021-04-30 application 17246466
- Type
- Utility · 32 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
Source: PTBLXML, file of 2026-07-21 (ipgb20260721.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Broad Institute, Inc. 503 patents | US company or organization | Cambridge, MA | BROAD INSTITUTE INC Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-07-21 |
| Massachusetts Institute of Technology 5,106 patents | US company or organization | Cambridge, MA | Massachusetts Institute of Technology College or university EXACT high confidence: identical full name and state MASSACHUSETTS INSTITUTE OF TECHNOLOGY Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-07-21 |
| President and Fellows of Harvard College 2,238 patents | US company or organization | Cambridge, MA | Harvard University College or university EXACT high confidence: through the nonprofit with the college's EIN (identical full name and state) PRESIDENT & FELLOWS OF HARVARD COLLEGE Form D issuer EXACT high confidence: identical full name and state PRESIDENT AND FELLOWS OF HARVARD COLLEGE Federal lobbying client EXACT high confidence: identical full name and state PRESIDENT AND FELLOWS OF HARVARD COLLEGE Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-07-21 |
| Rutgers, the State University of New Jersey 917 patents | US company or organization | New Brunswick, NJ | RUTGERS - THE STATE UNIVERSITY OF NEW JERSEY Federal lobbying client EXACT high confidence: identical full name and state | PTBLXML, file of 2026-07-21 |
| Skolkovo Institute of Science and Technology 11 patents | Foreign company or organization | Moscow, RU | PTBLXML, file of 2026-07-21 | |
| The United States of America, as represented by the Secretary, Department of Health and Human Services | US federal government | Bethesda, MD | PTBLXML, file of 2026-07-21 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Eugene Koonin | Bethesda, MD | 7 | PTBLXML, file of 2026-07-21 | |
| Feng Zhang | Cambridge, MA | PTBLXML, file of 2026-07-21 | ||
| Yuri I. Wolf | Bethesda, MD | 7 | PTBLXML, file of 2026-07-21 | |
| Sergey Shmakov | Moscow, RU | 8 | PTBLXML, file of 2026-07-21 | |
| Konstantin Severinov | New Brunswick, NJ | 10 | PTBLXML, file of 2026-07-21 | |
| Ekaterina Semenova | New Brunswick, NJ | 7 | PTBLXML, file of 2026-07-21 | |
| Leonid Minakhin | New Brunswick, MD | 6 | PTBLXML, file of 2026-07-21 | |
| Kira S. Makarova | Bethesda, MD | 7 | PTBLXML, file of 2026-07-21 | |
| Silvana Konermann | Cambridge, MA | 28 | PTBLXML, file of 2026-07-21 | |
| Julia Joung | Cambridge, MA | 11 | PTBLXML, file of 2026-07-21 | |
| Jonathan S. Gootenberg | Cambridge, MA | PTBLXML, file of 2026-07-21 | ||
| Omar O. Abudayyeh | Cambridge, MA | PTBLXML, file of 2026-07-21 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/102 | PTBLXML, file of 2026-07-21 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K48/005 | PTBLXML, file of 2026-07-21 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2021-05-04 | Assignment Assignment of assignor's interest | SEVERINOV, KONSTANTIN signed 2018-02-05 | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY NEW BRUNSWICK, NJ | 56177/453 | PASDL, file of 2026-10-15 |
| 2021-05-04 | Assignment Partial assignment | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY signed 2018-06-25 | SKOLKOVO INSTITUTE OF SCIENCE AND TECHNOLOGY MOSCOW REGION | 56157/652 | PASDL, file of 2026-10-15 |
| 2021-05-04 | Assignment Assignment of assignor's interest | SEMENOVA, EKATERINA signed 2018-01-17 MINAKHIN, LEONID signed 2018-01-17 | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY NEW BRUNSWICK, NJ | 56128/758 | PASDL, file of 2026-10-15 |
| 2021-05-04 | Assignment Assignment of assignor's interest | ZHANG, FENG signed 2018-08-15 | THE BROAD INSTITUTE, INC. CAMBRIDGE, MA MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA | 56128/212 | PASDL, file of 2026-10-15 |
| 2021-05-04 | Assignment Assignment of assignor's interest | WOLF, YURI I. signed 2019-04-26 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES BETHESDA, MD | 56127/862 | PASDL, file of 2026-10-15 |
| 2021-05-04 | Assignment Assignment of assignor's interest | MAKAROVA, KIRA S. signed 2019-05-22 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES BETHESDA, MD | 56127/606 | PASDL, file of 2026-10-15 |
| 2021-05-04 | Assignment Assignment of assignor's interest | KOONIN, EUGENE signed 2019-04-26 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES BETHESDA, MD | 56127/201 | PASDL, file of 2026-10-15 |
| 2021-05-04 | Assignment Assignment of assignor's interest | KONERMANN, SILVANA signed 2018-11-05 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA | 56126/926 | PASDL, file of 2026-10-15 |
| 2021-05-04 | Assignment Assignment of assignor's interest | JOUNG, JULIA signed 2018-08-15 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA | 56126/670 | PASDL, file of 2026-10-15 |
| 2021-05-04 | Assignment Assignment of assignor's interest | GOOTENBERG, JONATHAN signed 2018-08-15 | PRESIDENT AND FELLOWS OF HARVARD COLLEGE CAMBRIDGE, MA | 56126/512 | PASDL, file of 2026-10-15 |
| 2021-05-04 | Assignment Assignment of assignor's interest | ABUDAYYEH, OMAR O. signed 2018-08-15 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA | 56126/199 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.