Patents
US 12686853 B2: Methods and compositions for treatment of muscle disease with iPSC-induced human skeletal muscle stem cells
- Granted
- 2026-07-21
- Filed
- 2021-10-25 application 18033756
- Type
- Utility · 13 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Human skeletal muscle stem cells were generated from facioscapulohumeral muscular dystrophy (FSHD) and healthy control iPSC using a transgene-free skeletal muscle differentiation protocol and production of stable iMyoblasts. Analyses revealed that FSHD and healthy control iMyoblasts are embryonic-like myogenic cells that undergo myotube differentiation ex vivo by growth factor depletion and are efficiently transplantable into the tibialis anterior (TA) muscles of NSG mice, where human muscle under-goes embryonic-to-adult myosin isoform switching. The DUX4 FSHD disease gene maintains its hypomethylated disease state inFSHD iPSC and iMyoblast, and its expression is upregulated during myotube differentiation and in muscle xenografts. Consequently, these iMyoblasts accurately exhibit the molecular pathology of human muscular dystrophies and are useful for the development of drug, gene editing and stem cell therapeutics.
Source: PTBLXML, file of 2026-07-21 (ipgb20260721.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| UNIVERSITY OF MASSACHUSETTS 1,152 patents | US company or organization | Westborough, MA | UNIVERSITY OF MASSACHUSETTS Federal lobbying client EXACT high confidence: identical full name and state | PTBLXML, file of 2026-07-21 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Charles P. Emerson | Lyndon, VT | 3 | PTBLXML, file of 2026-07-21 | |
| Dongsheng Guo | Shrewsbury, MA | 55 | PTBLXML, file of 2026-07-21 | |
| Katelyn M. Daman | Stow, MA | PTBLXML, file of 2026-07-21 | ||
| Jing Yan | Shrewsbury, MA | PTBLXML, file of 2026-07-21 | ||
| Jennifer Chee-Jen Chen | Kingston, CA | PTBLXML, file of 2026-07-21 | ||
| Meng-jiao Shi | Shrewsbury, MA | PTBLXML, file of 2026-07-21 | ||
| Oliver D. King | Somerville, MA | 4 | PTBLXML, file of 2026-07-21 | |
| Lawrence J. Hayward | Sterling, MA | PTBLXML, file of 2026-07-21 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N5/0658 | PTBLXML, file of 2026-07-21 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2026-01-06 | Assignment Assignment of assignor's interest | EMERSON, CHARLES P. signed 2025-11-25 GUO, DONGSHENG signed 2025-11-24 DAMAN, KATELYN M. signed 2025-11-24 YAN, JING signed 2025-11-24 CHEN, JENNIFER CHEE-JEAN signed 2025-11-25 SHI, MENG-JIAO signed 2026-01-06 KING, OLIVER D. signed 2025-11-24 HAYWARD, LAWRENCE J. signed 2025-11-24 | UNIVERSITY OF MASSACHUSETTS BOSTON, MA | 73382/311 | PASDL, file of 2026-08-13 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.