Patents
US 12686849 B2: Compositions and methods for improving embryo development
- Granted
- 2026-07-21
- Filed
- 2024-02-13 application 18440821
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Compositions and methods for improving embryo development, treating idiopathic male factor infertility, and enabling infertile/sub-fertile/sterile men to father their own genetic offspring are provided. Typically, the methods include administering into a male or female gamete or fertilized embryo an effective amount of a compound that increases bioavailability of a TET protein to improve development of an embryo resulting from fertilization of the female gamete by a male gamete. The compound can be administered into the gamete or embryo before, during, or after fertilization. The compound can be administered by an injection such as intracytoplasmic injection. The compound and the male gamete can be administered in combination by intracytoplasmic sperm injection. Methods of making male gametes, and methods of modifying the genome of a male gamete or embryo using an effective amount of a gene editing composition to correct a gene mutation or anomaly in the genome thereof are also provided.
Source: PTBLXML, file of 2026-07-21 (ipgb20260721.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| University of Georgia Research Foundation, Inc. 535 patents | US company or organization | Athens, GA | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. State business registration EXACT high confidence: identical full name and state UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-07-21 |
| Emory University 646 patents | US company or organization | Atlanta, GA | Emory University College or university EXACT high confidence: identical full name and state | PTBLXML, file of 2026-07-21 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Charles A. Easley, IV | Athens, GA | 2 | PTBLXML, file of 2026-07-21 | |
| Anthony W.S. Chan | Atlanta, GA | PTBLXML, file of 2026-07-21 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N5/0604 | PTBLXML, file of 2026-07-21 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-02-21 | Assignment Assignment of assignor's interest | EASLEY, CHARLES A., IV signed 2019-09-12 | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. ATHENS, GA | 66513/44 | PASDL, file of 2026-08-13 |
| 2024-02-21 | Assignment Assignment of assignor's interest | CHAN, ANTHONY W.S. signed 2019-08-26 | EMORY UNIVERSITY ATLANTA, GA | 66512/970 | PASDL, file of 2026-08-13 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.