Patents
US 12686716 B2: Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
- Granted
- 2026-07-21
- Filed
- 2025-04-29 application 19193629
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The disclosure provides a method for immunotherapy of a subject afflicted with cancer, comprises administering to the subject a composition comprising a therapeutically effective amount of an antibody that inhibits signaling from the PD-1/PD-L1 signaling pathway. This disclosure also provides a method for immunotherapy of a subject afflicted with cancer comprising selecting a subject that is a suitable candidate for immunotherapy based on an assessment that the proportion of cells in a test tissue sample from the subject that express PD-L1 on the cell surface exceeds a predetermined threshold level, and administering a therapeutically effective amount of an anti-PD-1 antibody to the selected subject. The invention additionally provides rabbit mAbs that bind specifically to a cell surface-expressed PD-L1 antigen in a FFPE tissue sample, and an automated IHC method for assessing cell surface expression in FFPE tissues using the provided anti-PD-L1 Abs.
Source: PTBLXML, file of 2026-07-21 (ipgb20260721.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Bristol-Myers Squibb Company 1,812 patents | US company or organization | Princeton, NJ | BRISTOL MYERS SQUIBB CO SEC filer FUZZY low confidence: same name (legal endings aside), one of each nationally | PTBLXML, file of 2026-07-21 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| John P. Cogswell | Yardley, PA | 20 | PTBLXML, file of 2026-07-21 | |
| Stacie M. Goldberg | Potomac, MD | 18 | PTBLXML, file of 2026-07-21 | |
| Ashok K Gupta | Clarksburg, MD | 22 | PTBLXML, file of 2026-07-21 | |
| Maria Jure-Kunkel | Plainsboro, NJ | 39 | PTBLXML, file of 2026-07-21 | |
| Xi-Tao Wang | Wellesley, MA | 25 | PTBLXML, file of 2026-07-21 | |
| Jon M. Wigginton | Collegeville, PA | 22 | PTBLXML, file of 2026-07-21 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K16/2818 | PTBLXML, file of 2026-07-21 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K39/3955 | PTBLXML, file of 2026-07-21 |
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N33/5759 | PTBLXML, file of 2026-07-21 |
| Y02A | Technologies for adaptation to climate change | Y02A50/30 | PTBLXML, file of 2026-07-21 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2026-07-09 | Assignment Assignment of assignor's interest | COGSWELL, JOHN P. signed 2013-06-10 GOLDBERG, STACIE M. signed 2013-06-18 GUPTA, ASHOK K. signed 2013-06-10 JURE-KUNKEL, MARIE signed 2013-06-19 WANG, XI-TAO signed 2013-06-10 WIGGINGTON, JON M. signed 2013-07-17 | BRISTOL-MYERS SQUIBB COMPANY PRINCETON, NJ | 75966/276 | PASDL, file of 2026-09-12 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.