Patents
US 12685776 B2: Arginine methyltransferase 5 (PRMT5) degraders and uses thereof
- Granted
- 2026-07-21
- Filed
- 2021-04-05 application 17917075
- Type
- Utility · 24 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed are to bifunctional compounds that target PRMT5 for degradation, compositions, and methods for treating diseases or conditions mediated by aberrant arginine methyltransferase 5 (PRMT5) activity.
Source: PTBLXML, file of 2026-07-21 (ipgb20260721.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| DANA-FARBER CANCER INSTITUTE, INC. 892 patents | US company or organization | Boston, MA | DANA-FARBER CANCER INSTITUTE, INC. Federal lobbying client EXACT high confidence: identical full name and state DANA-FARBER CANCER INSTITUTE Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-07-21 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jun Qi | Sharon, MA | 40 | PTBLXML, file of 2026-07-21 | |
| Lei Wu | Allston, MA | 27 | PTBLXML, file of 2026-07-21 | |
| Paul M. Park | Waltham, MA | 4 | PTBLXML, file of 2026-07-21 | |
| Logan H. Sigua | North Sutton, NH | PTBLXML, file of 2026-07-21 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K47/55 | PTBLXML, file of 2026-07-21 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P11/00 | PTBLXML, file of 2026-07-21 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-09-20 | Assignment Assignment of assignor's interest | WU, LEI signed 2023-09-16 | DANA-FARBER CANCER INSTITUTE, INC. BOSTON, MA | 64972/834 | PASDL, file of 2026-08-13 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.