Patents
US 12682983 B2: Methods of quality control using single-nucleotide polymorphisms in pre-implantation genetic screening
- Granted
- 2026-07-14
- Filed
- 2020-08-05 application 16985980
- Type
- Utility · 19 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention provides methods for validating results of a pre-implantation genetic screen. Methods of the invention increase the efficacy of the common PGS assay FAST-SeqS by taking advantage of single-nucleotide polymorphisms (SNPs) generated from the assay to confirm copy number calls, detect errors, identify samples, and recognize and identify sources of contamination. Methods of the invention increase the reliability of a PGS result, thereby making embryo selection more precise and improving outcomes of in vitro fertilization.
Source: PTBLXML, file of 2026-07-14 (ipgb20260714.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Laboratory Corporation of America Holdings 128 patents | US company or organization | Burlington, NC | PTBLXML, file of 2026-07-14 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Mark Umbarger | Brookline, MA | PTBLXML, file of 2026-07-14 | ||
| Athurva Gore | Cambridge, MA | PTBLXML, file of 2026-07-14 | ||
| Gregory Porreca | Cambridge, MA | PTBLXML, file of 2026-07-14 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| G16B | Bioinformatics, i.e. information and communication technology [ict] specially adapted for genetic or protein-related data processing in computational molecular biology | G16B30/00 | PTBLXML, file of 2026-07-14 |
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/6809 | PTBLXML, file of 2026-07-14 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-08-30 | Assignment Assignment of assignor's interest | INVITAE CORPORATION signed 2024-08-05 | LABORATORY CORPORATION OF AMERICA HOLDINGS BURLINGTON, NC | 68822/25 | PASDL, file of 2026-10-15 |
| 2023-03-13 | Security interest Security interest Security interest | INVITAE CORPORATION signed 2023-03-07 | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT ST. PAUL, MN | 63787/148 | PASDL, file of 2026-10-15 |
| 2023-03-06 | Release of security interest Release of security interest | PERCEPTIVE CREDIT HOLDINGS III, LP signed 2023-02-28 | INVITAE CORPORATION SAN FRANCISCO, CA GOOD START GENETICS, INC. SAN FRANCISCO, CA SINGULAR BIO, INC. SAN FRANCISCO, CA YOUSCRIPT, LLC SAN FRANCISCO, CA | 63282/538 | PASDL, file of 2026-10-15 |
| 2021-10-11 | Correction Corrective assignment to correct the the schedule a of the confirmatory assignment previously recorded at reel: 056756 frame: 0884. assignor(s) hereby confirms the assignment. | GOOD START GENETICS, INC. signed 2021-06-15 | INVITAE CORPORATION SAN FRANCISCO, CA | 57772/828 | PASDL, file of 2026-10-15 |
| 2021-09-01 | Assignment Assignment of assignor's interest | UMBARGER, MARK signed 2015-04-06 GORE, ATHURVA signed 2015-04-06 PORRECA, GREGORY signed 2015-04-01 | GOOD START GENETICS, INC. CAMBRIDGE, MA | 57352/866 | PASDL, file of 2026-10-15 |
| 2021-07-02 | Assignment Assignment of assignor's interest | GOOD START GENETICS, INC. signed 2021-06-15 | INVITAE CORPORATION SAN FRANCISCO, CA | 56756/884 | PASDL, file of 2026-10-15 |
| 2020-10-02 | Security interest Security interest Patent security agreement | INVITAE CORPORATION signed 2020-10-02 GOOD START GENETICS, INC. signed 2020-10-02 SINGULAR BIO, INC. signed 2020-10-02 YOUSCRIPT, LLC signed 2020-10-02 | PERCEPTIVE CREDIT HOLDINGS III, LP NEW YORK, NY | 54234/872 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.