Patents
US 12679842 B2: HCK as a therapeutic target in MYD88 mutated diseases
- Granted
- 2026-07-14
- Filed
- 2020-10-07 application 17767413
- Type
- Utility · 11 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., HCK, BTK, LYN, BLK, FRK) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating diseases (e.g., proliferative diseases) in a subject in need thereof).
Source: PTBLXML, file of 2026-07-14 (ipgb20260714.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| DANA-FARBER CANCER INSTITUTE, INC. 892 patents | US company or organization | Boston, MA | DANA-FARBER CANCER INSTITUTE, INC. Federal lobbying client EXACT high confidence: identical full name and state DANA-FARBER CANCER INSTITUTE Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-07-14 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Steven P. Treon | Jamaica Plain, MA | 15 | PTBLXML, file of 2026-07-14 | |
| Nathanael S. Gray | Stanford, CA | 178 | PTBLXML, file of 2026-07-14 | |
| Sara Jean Buhrlage | Somerville, MA | 21 | PTBLXML, file of 2026-07-14 | |
| Guang Yang | Natick, MA | 191 | PTBLXML, file of 2026-07-14 | |
| Jinhua Wang | Winchester, MA | 37 | PTBLXML, file of 2026-07-14 | |
| Li Tan | Pudong, CN | 15 | PTBLXML, file of 2026-07-14 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D487/04 | PTBLXML, file of 2026-07-14 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-12-27 | Assignment Assignment of assignor's interest | TREON, STEVEN P signed 2022-10-19 GRAY, NATHANAEL S. signed 2022-10-03 BUHRLAGE, SARA JEAN signed 2022-10-03 YANG, GUANG signed 2022-10-03 WANG, JINHUA signed 2022-10-03 TAN, LI signed 2022-10-07 | DANA-FARBER CANCER INSTITUTE, INC. BOSTON, MA | 62211/373 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.