Patents
US 12678508 B2: Compounds for targeted degradation of interleukin-2-inducible T-cell kinase and methods of use
- Granted
- 2026-07-14
- Filed
- 2021-06-22 application 18010699
- Type
- Utility · 27 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed are bispecific compounds (degraders) that target ITK or a zinc finger (ZnF) protein for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat diseases and disorders characterized or mediated by ITK or ZnF protein activity.
Source: PTBLXML, file of 2026-07-14 (ipgb20260714.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| DANA-FARBER CANCER INSTITUTE, INC. 892 patents | US company or organization | Boston, MA | DANA-FARBER CANCER INSTITUTE, INC. Federal lobbying client EXACT high confidence: identical full name and state DANA-FARBER CANCER INSTITUTE Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-07-14 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Nathanael S. Gray | Stanford, CA | 178 | PTBLXML, file of 2026-07-14 | |
| Baishan Jiang | Watertown, MA | 7 | PTBLXML, file of 2026-07-14 | |
| David Weinstock | Jamaica Plain, MA | 8 | PTBLXML, file of 2026-07-14 | |
| Wenchao Wu | Brookline, MA | PTBLXML, file of 2026-07-14 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K47/545 | PTBLXML, file of 2026-07-14 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PTBLXML, file of 2026-07-14 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.