Patents
US 12673952 B2: Processes for preparing modulators of alpha-1 antitrypsin
- Granted
- 2026-07-07
- Filed
- 2021-07-26 application 18018245
- Type
- Utility · 5 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
This disclosure provides large-scale processes for preparing a modulator of alpha-1 antitrypsin (AAT) activity that may be useful for treating alpha-1 antitrypsin deficiency (AATD), such as 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1), 3-[5-(4-fluorophenyl)-6-isopropyl-1H-pyrrolo[2,3-f]indazol-7-yl]propanoic acid (Compound 2), or a pharmaceutically acceptable salt of any of the foregoing.
Source: PTBLXML, file of 2026-07-07 (ipgb20260707.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Vertex Pharmaceuticals Incorporated 764 patents | US company or organization | Boston, MA | PTBLXML, file of 2026-07-07 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Cavan McKeon Bligh | Melrose, MA | 5 | PTBLXML, file of 2026-07-07 | |
| Robert Daniel Giacometti | Malden, MA | 3 | PTBLXML, file of 2026-07-07 | |
| Cristian Harrison | Beverly, MA | 10 | PTBLXML, file of 2026-07-07 | |
| Stephen W. Laws | Dorchester, MA | PTBLXML, file of 2026-07-07 | ||
| Adam Looker | Newtonville, MA | 25 | PTBLXML, file of 2026-07-07 | |
| Stefanie Roeper | Medford, MA | 20 | PTBLXML, file of 2026-07-07 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D487/04 | PTBLXML, file of 2026-07-07 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-12-28 | Assignment Assignment of assignor's interest | ROEPER, STEFANIE signed 2021-06-21 LOOKER, ADAM signed 2021-07-21 HARRISON, CRISTIAN signed 2021-07-26 BLIGH, CAVAN MCKEON signed 2021-07-21 LAWS, STEPHEN W. signed 2021-07-21 GIACOMETTI, ROBERT DANIEL signed 2021-07-22 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 65968/770 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.