Patents
US 12673931 B2: Compounds for disease treatment
- Granted
- 2026-07-07
- Filed
- 2022-01-25 application 18273843
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure provides compounds according to Formula (I), wherein X, R2, R3, R4, and R5 are defined herein. Further disclosed herein are pharmaceutical compositions, orally administrable dosage forms, and methods for using such compounds in the treatment of various diseases and disorders including inflammation, autoimmune disorders, chronic pain and cancer. In particular embodiments, the present disclosure provides orally bioavailable compounds capable of selectively modulating an activity (e.g., inhibition) of the serine/threonine protein kinase TAK1 and/or related kinases.
Source: PTBLXML, file of 2026-07-07 (ipgb20260707.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Duke University 1,375 patents | US company or organization | Durham, NC | Duke University College or university EXACT high confidence: identical full name and state DUKE UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-07-07 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Scott Scarneo | Durham, NC | PTBLXML, file of 2026-07-07 | ||
| Philip F. Hughes | Durham, NC | 14 | PTBLXML, file of 2026-07-07 | |
| Andrea Neely | Durham, NC | PTBLXML, file of 2026-07-07 | ||
| Timothy A.J. Haystead | Durham, NC | PTBLXML, file of 2026-07-07 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D401/06 | PTBLXML, file of 2026-07-07 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P11/00 | PTBLXML, file of 2026-07-07 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2025-12-03 | Assignment Assignment of assignor's interest | SCARNEO, SCOTT signed 2023-08-28 HUGHES, PHILIP F. signed 2023-08-17 NEELY, ANDREA signed 2024-12-01 HAYSTEAD, TIMOTHY A.J. signed 2024-02-06 | DUKE UNIVERSITY DURHAM, NC | 73107/42 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.