Patents
US 12668571 B2: Substituted 3-amino-4-methylbenzenesulfonamides as small molecule inhibitors of ubiquitin-specific protease 28
- Granted
- 2026-06-30
- Filed
- 2021-08-10 application 18020492
- Type
- Utility · 21 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof and pharmaceutical composition comprising the compound of formula (I). The present composition also relates to methods treating a disease or disorder associated with ubiquitin-specific protease 28 (USP28), methods of treating cancer, and methods of inhibiting USP28.
Source: PTBLXML, file of 2026-06-30 (ipgb20260630.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Dana-Farber Cancer Institute, Inc. 892 patents | US company or organization | Boston, MA | DANA-FARBER CANCER INSTITUTE, INC. Federal lobbying client EXACT high confidence: identical full name and state DANA-FARBER CANCER INSTITUTE Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-06-30 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Sara Buhrlage | Somerville, MA | PTBLXML, file of 2026-06-30 | ||
| Anthony Varca | Brookline, MA | 6 | PTBLXML, file of 2026-06-30 | |
| Bin Hu | Natick, MA | PTBLXML, file of 2026-06-30 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07C | Acyclic or carbocyclic compounds | C07C311/46 | PTBLXML, file of 2026-06-30 |
| C07D | Heterocyclic compounds | C07D233/61 | PTBLXML, file of 2026-06-30 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-07-13 | Assignment Assignment of assignor's interest | BUHRLAGE, SARAH signed 2023-06-29 VARCA, ANTHONY signed 2023-06-23 HU, BIN signed 2023-06-29 | DANA-FARBER CANCER INSTITUTE, INC. BOSTON, MA | 64244/925 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.