Patents
US 12667628 B2: Compositions and methods for gene replacement
- Granted
- 2026-06-30
- Filed
- 2020-07-02 application 17624145
- Type
- Utility · 18 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention features a dual vector system for disrupting and replacing a target gene comprising a mutation (e.g., dominant, recessive mutation). Embodiments of the invention may also provide compositions comprising the dual vector system, and methods of using the dual vector system, including but not limited to methods of modifying the genome of a cell, methods of genomic editing, and methods of treating cells or a subject suffering from a genetic disease comprising a mutation.
Source: PTBLXML, file of 2026-06-30 (ipgb20260630.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Children's Medical Center Corporation 717 patents | US company or organization | Boston, MA | THE CHILDREN'S MEDICAL CENTER CORPORATION State business registration FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-06-30 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jeffrey R. Holt | Boston, MA | PTBLXML, file of 2026-06-30 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K48/005 | PTBLXML, file of 2026-06-30 |
| C07K | Peptides | C07K14/705 | PTBLXML, file of 2026-06-30 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/22 | PTBLXML, file of 2026-06-30 |
| A01K | Animal husbandry; aviculture; apiculture; pisciculture; fishing; rearing or breeding animals, not otherwise provided for; new breeds of animals | A01K2217/075 | PTBLXML, file of 2026-06-30 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2025-02-24 | Assignment Assignment of assignor's interest | HOLT, JEFFREY R. signed 2021-07-30 | CHILDREN'S MEDICAL CENTER CORPORATION BOSTON, MA | 70311/33 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.