Patents
US 12662470 B2: Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels
- Granted
- 2026-06-23
- Filed
- 2022-06-03 application 18566305
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
Source: PTBLXML, file of 2026-06-23 (ipgb20260623.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| VERTEX PHARMACEUTICALS INCORPORATED 764 patents | US company or organization | Boston, MA | PTBLXML, file of 2026-06-23 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Elizabeth Mary Beck | Abingdon, GB | 27 | PTBLXML, file of 2026-06-23 | |
| Robert Pullin | Oxford, GB | 9 | PTBLXML, file of 2026-06-23 | |
| Gorka Etxebarria Jardi | Badalona, ES | 6 | PTBLXML, file of 2026-06-23 | |
| Dean Stamos | Lexington, MA | 33 | PTBLXML, file of 2026-06-23 | |
| Yvonne Schmidt | San Diego, CA | 11 | PTBLXML, file of 2026-06-23 | |
| Joseph Pontillo | San Diego, CA | 12 | PTBLXML, file of 2026-06-23 | |
| Stephen Andrew Thomson | Durham, NC | 16 | PTBLXML, file of 2026-06-23 | |
| David Matthew Shaw | Oxford, GB | 24 | PTBLXML, file of 2026-06-23 | |
| Nadia M. Ahmad | Hayes, GB | PTBLXML, file of 2026-06-23 | ||
| Lidio Marx Carvalho Meireles | San Marcos, CA | 11 | PTBLXML, file of 2026-06-23 | |
| Sarah Skerratt | Cambridge, GB | PTBLXML, file of 2026-06-23 | ||
| Sara S. Hadida Ruah | La Jolla, CA | PTBLXML, file of 2026-06-23 | ||
| Timothy Donald Neubert | San Diego, CA | PTBLXML, file of 2026-06-23 | ||
| Dennis James Hurley | San Marcos, CA | 40 | PTBLXML, file of 2026-06-23 | |
| Steven John Durrant | Headington, GB | PTBLXML, file of 2026-06-23 | ||
| Christopher Wray | Berkshire, GB | 6 | PTBLXML, file of 2026-06-23 | |
| Anisa Nizarali Virani | Thatcham, GB | PTBLXML, file of 2026-06-23 | ||
| Kiri North | Oxford, GB | 7 | PTBLXML, file of 2026-06-23 | |
| Bhairavi Galan | Abingdon, GB | 6 | PTBLXML, file of 2026-06-23 | |
| Ronald Marcellus Knegtel | Abingdon, GB | PTBLXML, file of 2026-06-23 | ||
| Ewa Iwona Chudyk | Wantage, GB | 8 | PTBLXML, file of 2026-06-23 | |
| Joanne Louise Pinder | Didcot, GB | PTBLXML, file of 2026-06-23 | ||
| Bruno Artur Sousa | Reading, GB | PTBLXML, file of 2026-06-23 | ||
| Francoise Pierard | Abingdon, GB | 35 | PTBLXML, file of 2026-06-23 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D405/12 | PTBLXML, file of 2026-06-23 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/443 | PTBLXML, file of 2026-06-23 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-12-20 | Assignment Assignment of assignor's interest | VERTEX PHARMACEUTICALS (EUROPE) LIMITED signed 2023-10-31 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 65923/29 | PASDL, file of 2026-10-15 |
| 2023-12-20 | Assignment Assignment of assignor's interest | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC signed 2023-01-17 | INCORPORATED, VERTEX PHARMACEUTICALS BOSTON, MA | 65922/969 | PASDL, file of 2026-10-15 |
| 2023-12-20 | Assignment Assignment of assignor's interest | DURRANT, STEVEN JOHN signed 2022-10-13 SKERRATT, SARAH signed 2022-10-28 PULLIN, ROBERT signed 2022-10-12 ETXEBARRIA JARDI, GORKA signed 2022-12-04 SHAW, DAVID MATTHEW signed 2022-10-24 AHMAD, NADIA M. signed 2022-10-24 BECK, ELIZABETH MARY signed 2022-10-13 WRAY, CHRISTOPHER signed 2022-10-13 VIRANI, ANISA NIZARALI signed 2022-10-18 NORTH, KIRI signed 2022-10-13 GALAN, BHAIRAVI signed 2022-10-18 KNEGTEL, RONALD MARCELLUS signed 2022-10-13 CHUDYK, EWA IWONA signed 2022-10-18 PINDER, JOANNE LOUISE signed 2022-10-13 SOUSA, BRUNO ARTUS signed 2022-10-18 PIERARD, FRANCOISE signed 2023-04-19 | VERTEX PHARMACEUTICALS (EUROPE) LIMITED LONDON | 65922/943 | PASDL, file of 2026-10-15 |
| 2023-12-20 | Assignment Assignment of assignor's interest | STAMOS, DEAN signed 2022-10-27 SCHMIDT, YVONNE signed 2022-10-05 PONTILLO, JOSEPH signed 2022-10-07 HADIDA RUAH, SARA S. signed 2022-10-17 NEUBERT, TIMOTHY DONALD signed 2022-10-12 HURLEY, DENNIS JAMES signed 2022-10-18 | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC SAN DIEGO, CA | 65922/866 | PASDL, file of 2026-10-15 |
| 2023-12-20 | Assignment Assignment of assignor's interest | THOMSON, STEPHEN ANDREW signed 2022-10-14 CARVALHO MEIRELES, LIDIO MARX signed 2022-10-14 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 65922/832 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.