Patents
US 12661412 B2: Method to enhance the efficiency of systemic AAV gene delivery to the central nervous system
- Granted
- 2026-06-23
- Filed
- 2023-10-20 application 18490841
- Type
- Utility · 6 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The disclosure relates, in some aspects, to compositions and methods for enhanced delivery of a transgene to the central nervous system (CNS) of a subject. In some embodiments, the transgene is delivered by recombinant AAV (rAAV). In some embodiments, the method of enhancing transgene delivery comprises administering a blood brain barrier (BBB)-crossing molecule (e.g., K16ApoE) and an rAAV comprising a transgene to a subject.
Source: PTBLXML, file of 2026-06-23 (ipgb20260623.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| University of Massachusetts 1,152 patents | US company or organization | Westborough, MA | UNIVERSITY OF MASSACHUSETTS Federal lobbying client EXACT high confidence: identical full name and state | PTBLXML, file of 2026-06-23 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Miguel Sena Esteves | Worcester, MA | 17 | PTBLXML, file of 2026-06-23 | |
| Ana Rita Batista | Worcester, MA | 4 | PTBLXML, file of 2026-06-23 | |
| Sourav Roy Choudhury | Worcester, MA | 12 | PTBLXML, file of 2026-06-23 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K48/0008 | PTBLXML, file of 2026-06-23 |
| C07K | Peptides | C07K14/775 | PTBLXML, file of 2026-06-23 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/63 | PTBLXML, file of 2026-06-23 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-01-17 | Assignment Assignment of assignor's interest | ESTEVES, MIGUEL SENA signed 2017-07-31 BATISTA, ANA RITA signed 2017-08-01 CHOUDHURY, SOURAV ROY signed 2017-06-21 | UNIVERSITY OF MASSACHUSETTS BOSTON, MA | 66143/400 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.