Patents
US 12660769 B2: Heterozygous CENH3 monocots and methods of use thereof for haploid induction and simultaneous genome editing
- Granted
- 2026-06-23
- Filed
- 2021-06-09 application 18001370
- Type
- Utility · 19 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Monocot plants heterozygous for centromeric histone 3 (CenH3) and optionally expressing gene editing constructs, for use in inducing haploids of a monocot target plant and optionally pass-through gene editing are provided. The monocot haploid inducer plants are typically composed of diploid plant cells having only one allele encoding a functional CENH3 protein. The diploid plant cells can also include, for example, one CenH3 allele encoding non-functional CENH3 protein. In some embodiments, the allele encoding non-functional CENH3 protein is a frameshift mutation, protein null allele, an RNA null allele, or a combination thereof. The monocot haploid inducer plant can also include gene editing machinery, such as a site-directed nuclease and optionally a guide RNA stably expressed by cells of the monocot plant. Methods of inducing formation of a target haploid monocot plant while optionally simultaneously modifying the target monocot plant's genome are also provided.
Source: PTBLXML, file of 2026-06-23 (ipgb20260623.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| University of Georgia Research Foundation, Inc. 535 patents | US company or organization | Athens, GA | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. State business registration EXACT high confidence: identical full name and state UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-06-23 |
| Cold Spring Harbor Laboratory 88 patents | US company or organization | Cold Spring Harbor, NY | Cold Spring Harbor Laboratory State business registration EXACT high confidence: identical full name and state | PTBLXML, file of 2026-06-23 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| R. Kelly Dawe | Athens, GA | PTBLXML, file of 2026-06-23 | ||
| David Jackson | Brooklyn, NY | 32 | PTBLXML, file of 2026-06-23 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A01H | New plants or ; non-transgenic; processes for obtaining them; plant reproduction by tissue culture techniques | A01H1/08 | PTBLXML, file of 2026-06-23 |
| C07K | Peptides | C07K14/415 | PTBLXML, file of 2026-06-23 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/22 | PTBLXML, file of 2026-06-23 |
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/6895 | PTBLXML, file of 2026-06-23 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-03-09 | Assignment Assignment of assignor's interest | JACKSON, DAVID signed 2021-09-08 | COLD SPRING HARBOR LABORATORY COLD SPRING HARBOR, NY | 62930/246 | PASDL, file of 2026-10-15 |
| 2023-03-09 | Assignment Assignment of assignor's interest | DAWE, R. KELLY signed 2021-07-06 | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. ATHENS, GA | 62930/207 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.