Patents
US 12637697 B2: Compositions and methods for generating physiological X chromosome inactivation
- Granted
- 2026-05-26
- Filed
- 2018-07-19 application 17260283
- Type
- Utility · 13 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention features compositions and methods for recapitulating physiological X-chromosome inactivation (XCI) in a cell, including a cell of any embryo generated by Somatic Cell Nuclear Transfer (SCNT). In one aspect, the invention features a method for generating physiological X chromosome inactivation in an embryo generated by SCNT, the method comprising injecting the embryo generated via SCNT with an H3K27me3-specific demethylase polypeptide or a polynucleotide encoding said demethylase. Disclosed herein are methods, compositions, and kits comprising an agent which increases the expression of genes encoding an H3K27me3-specific demethylase, or increases the activity of human H3K27me3-specific demethylase.
Source: PTBLXML, file of 2026-05-26 (ipgb20260526.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Children's Medical Center Corporation 717 patents | US company or organization | Boston, MA | THE CHILDREN'S MEDICAL CENTER CORPORATION State business registration FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-05-26 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Yi Zhang | Boston, MA | 86 | PTBLXML, file of 2026-05-26 | |
| Azusa Inoue | Boston, MA | 4 | PTBLXML, file of 2026-05-26 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/8775 | PTBLXML, file of 2026-05-26 |
| A01K | Animal husbandry; aviculture; apiculture; pisciculture; fishing; rearing or breeding animals, not otherwise provided for; new breeds of animals | A01K67/0278 | PTBLXML, file of 2026-05-26 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/443 | PTBLXML, file of 2026-05-26 |
| C12Y | Enzymes | C12Y114/11027 | PTBLXML, file of 2026-05-26 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-12-18 | Other License | BOSTON CHILDREN'S HOSPITAL signed 2023-07-27 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT BETHESDA, MD | 69730/15 | PASDL, file of 2026-10-15 |
| 2021-01-21 | Assignment Assignment of assignor's interest | ZHANG, YI signed 2018-08-03 INOUE, AZUSA signed 2018-08-08 | CHILDREN'S MEDICAL CENTER CORPORATION BOSTON, MA | 54989/896 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.