Patents
US 12637661 B2: Methods of enhancing stem cell differentiation into beta cells
- Granted
- 2026-05-26
- Filed
- 2022-11-11 application 18054860
- Type
- Utility · 60 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed herein are compositions and methods of enhancing stem cell differentiation into beta cells with use of one or more epigenetic modification compounds. The present disclosure also relates to compositions and methods of sorting and enriching the differentiated beta cells. The present disclosure also relates to compositions and methods of irradiating cell population for reducing proliferation.
Source: PTBLXML, file of 2026-05-26 (ipgb20260526.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Vertex Pharmaceuticals Incorporated 764 patents | US company or organization | Boston, MA | PTBLXML, file of 2026-05-26 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Felicia Pagliuca | Boston, MA | PTBLXML, file of 2026-05-26 | ||
| George Harb | Boston, MA | 21 | PTBLXML, file of 2026-05-26 | |
| Mads Gurtler | Cambridge, MA | PTBLXML, file of 2026-05-26 | ||
| Austin Thiel | Southborough, MA | 3 | PTBLXML, file of 2026-05-26 | |
| Jihad Yasin | Gardner, MA | 3 | PTBLXML, file of 2026-05-26 | |
| Evrett Thompson | Woburn, MA | 4 | PTBLXML, file of 2026-05-26 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N5/0676 | PTBLXML, file of 2026-05-26 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-02-21 | Assignment Assignment of assignor's interest | PAGLIUCA, FELICIA signed 2024-02-14 HARB, GEORGE signed 2023-10-16 GURTLER, MADS signed 2024-01-30 GAGLIA, JASON signed 2023-11-21 POH, YEH-CHUIN signed 2024-01-31 YE, LILLIAN signed 2023-12-01 THIEL, AUSTIN signed 2023-10-24 YASIN, JIHAD signed 2024-02-17 THOMPSON, EVRETT signed 2023-10-17 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 66511/363 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.