Patents
US 12630532 B2: Indole-substituted quinolines and their combination with Plk1 inhibitors for the treatment of cancer
- Granted
- 2026-05-19
- Filed
- 2022-06-21 application 18567275
- Type
- Utility · 28 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Indole-substituted quinolines (ISQs) are provided which may include a variety of substituted piperidines. Methods for treating cancers, including c-MYC-driven cancers, are described including administering the ISQs to a subject in need thereof. The compounds may be administered in combination with a polo-like kinase-1 (Plk1) inhibitor. The Plk1 and the compound may be administered in synergistically effective amounts.
Source: PTBLXML, file of 2026-05-19 (ipgb20260519.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| University of Kentucky Research Foundation 446 patents | US company or organization | Lexington, KY | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-05-19 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Chunming Liu | Lexington, KY | 34 | PTBLXML, file of 2026-05-19 | |
| David S Watt | Lexington, KY | 18 | PTBLXML, file of 2026-05-19 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D401/14 | PTBLXML, file of 2026-05-19 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/4709 | PTBLXML, file of 2026-05-19 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PTBLXML, file of 2026-05-19 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.