Patents
US 12624102 B2: CD147 chimeric antigen receptors and methods of use
- Granted
- 2026-05-12
- Filed
- 2020-02-28 application 17438741
- Type
- Utility · 22 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Modified single chain variable fragments (scFv) that specifically bind CD147 are provided. Also provided are chimeric antigen receptors (CARs) including the modified CD147 scFv, nucleic acids encoding the CARs, vectors including the nucleic acids encoding the CARs, and immune cells expressing the CARs. Methods of treating a subject with cancer including administering to the subject an immune cell expressing a disclosed CD147-CAR are also provided.
Source: PTBLXML, file of 2026-05-12 (ipgb20260512.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Rutgers, The State University of New Jersey 917 patents | US company or organization | New Brunswick, NJ | RUTGERS - THE STATE UNIVERSITY OF NEW JERSEY Federal lobbying client EXACT high confidence: identical full name and state | PTBLXML, file of 2026-05-12 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Dongfang Liu | Millburn, NJ | 11 | PTBLXML, file of 2026-05-12 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K16/2803 | PTBLXML, file of 2026-05-12 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K40/11 | PTBLXML, file of 2026-05-12 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PTBLXML, file of 2026-05-12 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N5/0636 | PTBLXML, file of 2026-05-12 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2021-09-13 | Assignment Assignment of assignor's interest | LIU, DONGFANG signed 2020-05-16 | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY NEW BRUNSWICK, NJ | 57465/609 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.