Patents
US 12622952 B2: Formulations comprising recombinant acid α-glucosidase
- Granted
- 2026-05-12
- Filed
- 2022-11-07 application 18053151
- Type
- Utility · 28 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided are pharmaceutical formulations comprising a recombinant acid α-glucosidase, wherein the recombinant acid α-glucosidase is expressed in Chinese hamster ovary (CHO) cells and comprises an increased content of N-glycan units bearing one or two mannose-6-phosphate residues when compared to a content of N-glycan units bearing one or two mannose-6-phosphate residues of alglucosidase alfa; at least one buffer selected from the group consisting of a citrate, a phosphate and combinations thereof; and at least one excipient selected from the group consisting of mannitol, polysorbate 80, and combinations thereof, wherein the formulation has a pH of from about 5.0 to about 7.0. Also provided are methods of treating Pompe disease using these pharmaceutical formulations.
Source: PTBLXML, file of 2026-05-12 (ipgb20260512.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Amicus Therapeutics, Inc. 158 patents | US company or organization | Philadelphia, PA | AMICUS THERAPEUTICS, INC. Form D issuer EXACT high confidence: identical full name and state AMICUS THERAPEUTICS, INC. SEC filer EXACT medium confidence: identical full name, one of each nationally | PTBLXML, file of 2026-05-12 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Hing Char | East Brunswick, NJ | 6 | PTBLXML, file of 2026-05-12 | |
| Sergey Tesler | Monroe, NJ | 8 | PTBLXML, file of 2026-05-12 | |
| Wendy Sunderland | Doylestown, PA | 4 | PTBLXML, file of 2026-05-12 | |
| Enrique Diloné | Basking Ridge, NJ | 6 | PTBLXML, file of 2026-05-12 | |
| Russell Gotschall | Doylestown, PA | 17 | PTBLXML, file of 2026-05-12 | |
| Hung V. Do | New Hope, PA | 33 | PTBLXML, file of 2026-05-12 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/47 | PTBLXML, file of 2026-05-12 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/2408 | PTBLXML, file of 2026-05-12 |
| C12Y | Enzymes | C12Y302/0102 | PTBLXML, file of 2026-05-12 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2026-04-27 | Release of security interest Release of security interest | WILMINGTON TRUST, NATIONAL ASSOCIATION signed 2026-04-27 | AMICUS THERAPEUTICS, INC. PHILADELPHIA, PA | 75494/30 | PASDL, file of 2026-08-13 |
| 2026-04-27 | Security interest Security interest Security interest | BIOMARIN PHARMACEUTICAL INC. signed 2026-04-27 AMICUS THERAPEUTICS, INC. signed 2026-04-27 | CITIBANK, N.A., AS COLLATERAL AGENT NEW YORK, NY | 75493/968 | PASDL, file of 2026-10-15 |
| 2023-10-06 | Security interest Security interest Security interest | AMICUS THERAPEUTICS, INC. signed 2023-10-05 | WILMINGTON TRUST, NATIONAL ASSOCIATION MINNEAPOLIS, MN | 65177/196 | PASDL, file of 2026-10-15 |
| 2023-01-16 | Assignment Assignment of assignor's interest | CHAR, HING signed 2017-06-28 DILONE, ENRIQUE signed 2017-06-28 TESLER, SERGEY signed 2017-06-28 SUNDERLAND, WENDY signed 2017-06-28 | AMICUS THERAPEUTICS, INC. PHILADELPHIA, PA | 62384/534 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.