Patents
US 12618112 B2: Epigenetic moderators of naltrexone efficacy in reducing heavy drinking in individuals diagnosed with alcohol use disorder
- Granted
- 2026-05-05
- Filed
- 2022-05-25 application 17824784
- Type
- Utility · 8 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed are method for predicting naltrexone response in subjects with AUD. In some embodiments, the methods include performing or having performed one or more methylation assays on a genomic DNA sample isolated from the subject to determine the methylation status of one or more regions of the isolated genomic DNA, wherein the one or more regions are subsequences of a gene selected from a mu opioid receptor (OPRM1) gene, a catechol-O-methyltransferase (COMT) gene, and a dopamine transporter (SLC6A3) gene, wherein the methylation status of the one or more regions of the isolated genomic DNA determined is predictive of naltrexone response in the subject. Also provided are method for treating patients diagnosed with AUD with the medication naltrexone based on a methylation status of a combination of specific methylation sites located associated with an OPRM1 gene, a COMT gene, and/or an SLC6A3 gene in obtained from each AUD patient.
Source: PTBLXML, file of 2026-05-05 (ipgb20260505.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| MUSC Foundation for Research Development 149 patents | US company or organization | Charleston, SC | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-05-05 |
| The Regents of the University of Colorado 307 patents | US company or organization | Denver, CO | THE REGENTS OF THE UNIVERSITY OF COLORADO Federal lobbying client EXACT high confidence: identical full name and state REGENTS OF THE UNIVERSITY OF COLORADO Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-05-05 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Raymond F. Anton | Charleston, SC | PTBLXML, file of 2026-05-05 | ||
| Joseph P. Schacht | Denver, CO | PTBLXML, file of 2026-05-05 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/6883 | PTBLXML, file of 2026-05-05 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-08-21 | Assignment Assignment of assignor's interest | MEDICAL UNIVERSITY OF SOUTH CAROLINA signed 2022-11-21 | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT CHARLESTON, SC | 64650/237 | PASDL, file of 2026-10-15 |
| 2022-10-13 | Assignment Assignment of assignor's interest | SCHACHT, JOSEPH P signed 2022-07-13 | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE DENVER, CO MEDICAL UNIVERSITY OF SOUTH CAROLINA CHARLESTON, SC | 61415/927 | PASDL, file of 2026-10-15 |
| 2022-10-13 | Assignment Assignment of assignor's interest | ANTON, RAYMOND F signed 2022-07-15 | MEDICAL UNIVERSITY OF SOUTH CAROLINA CHARLESTON, SC | 61415/663 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.