Patents
US 12618054 B2: CRISPR/Cpf1 systems and methods
- Granted
- 2026-05-05
- Filed
- 2021-09-08 application 17469578
- Type
- Utility · 8 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
This invention pertains to recombinant AsCpf1 and LbCpf1 nucleic acids and polypeptides for use in CRISPR/Cpf1 endonuclease systems and mammalian cell lines encoding recombinant AsCpf1 or LbCpf1 polypeptides. The invention includes recombinant ribonucleoprotein complexes and CRSPR/Cpf1 endonuclease systems having a suitable AsCpf1 crRNA is selected from a length-truncated AsCpf1 crRNA, a chemically-modified AsCpf1 crRNA, or an AsCpf1 crRNA comprising both length truncations and chemical modifications. Methods of performing gene editing using these systems and reagents are also provided.
Source: PTBLXML, file of 2026-05-05 (ipgb20260505.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Integrated DNA Technologies, Inc. 103 patents | US company or organization | Coralville, IA | INTEGRATED DNA TECHNOLOGIES, INC. State business registration EXACT high confidence: identical full name and state | PTBLXML, file of 2026-05-05 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Mark Aaron Behlke | Coralville, IA | 74 | PTBLXML, file of 2026-05-05 | |
| Michael Allen Collingwood | North Liberty, IA | 19 | PTBLXML, file of 2026-05-05 | |
| Rolf Turk | Iowa City, IA | 3 | PTBLXML, file of 2026-05-05 | |
| Christopher Anthony Vakulskas | North Liberty, IA | 22 | PTBLXML, file of 2026-05-05 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/22 | PTBLXML, file of 2026-05-05 |
| C12Y | Enzymes | C12Y301/30 | PTBLXML, file of 2026-05-05 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2025-03-04 | Assignment Assignment of assignor's interest | VAKULSKAS, CHRISTOPHER ANTHONY signed 2021-09-02 | INTEGRATED DNA TECHNOLOGIES, INC. CORALVILLE, IA | 70390/981 | PASDL, file of 2026-10-15 |
| 2025-03-04 | Assignment Assignment of assignor's interest | BEHLKE, MARK AARON signed 2017-04-10 COLLINGWOOD, MICHAEL ALLEN signed 2017-04-10 TURK, ROLF signed 2017-04-10 | INTEGRATED DNA TECHNOLOGIES, INC. CORALVILLE, IA | 70390/912 | PASDL, file of 2026-10-15 |
| 2025-03-04 | Assignment Assignment of assignor's interest | BEHLKE, MARK AARON signed 2016-11-28 COLLINGWOOD, MICHAEL ALLEN signed 2016-11-28 TURK, ROLF signed 2016-11-28 | INTEGRATED DNA TECHNOLOGIES, INC. CORALVILLE, IA | 70390/826 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.