Patents
US 12612416 B2: Modulators of cystic fibrosis transmembrane conductance regulator
- Granted
- 2026-04-28
- Filed
- 2021-10-06 application 18248065
- Type
- Utility · 23 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.
Source: PTBLXML, file of 2026-04-28 (ipgb20260428.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Vertex Pharmaceuticals Incorporated 764 patents | US company or organization | Boston, MA | PTBLXML, file of 2026-04-28 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jason Mccartney | Cardiff by the Sea, CA | 73 | PTBLXML, file of 2026-04-28 | |
| Alexander Russell Abela | Escondido, CA | 10 | PTBLXML, file of 2026-04-28 | |
| Sunny Abraham | San Diego, CA | 18 | PTBLXML, file of 2026-04-28 | |
| Corey Don Anderson | Brighton, MA | PTBLXML, file of 2026-04-28 | ||
| Vijayalaksmi Arumugam | San Marcos, CA | 40 | PTBLXML, file of 2026-04-28 | |
| Jaclyn Chau | San Diego, CA | 5 | PTBLXML, file of 2026-04-28 | |
| Jeremy Clemens | San Diego, CA | PTBLXML, file of 2026-04-28 | ||
| Thomas Cleveland | San Marcos, CA | 30 | PTBLXML, file of 2026-04-28 | |
| Timothy A. Dwight | Quincy, MA | 2 | PTBLXML, file of 2026-04-28 | |
| Bryan A. Frieman | La Jolla, CA | 28 | PTBLXML, file of 2026-04-28 | |
| Peter Grootenhuis | Del Mar, CA | PTBLXML, file of 2026-04-28 | ||
| Sara Sabina Hadida Ruah | La Jolla, CA | 45 | PTBLXML, file of 2026-04-28 | |
| Yoshihiro Ishihara | San Diego, CA | 3 | PTBLXML, file of 2026-04-28 | |
| Paul Krenitsky | San Francisco, CA | 23 | PTBLXML, file of 2026-04-28 | |
| Mark Thomas Miller | Rancho Santa Fe, CA | PTBLXML, file of 2026-04-28 | ||
| Fabrice Pierre | La Jolla, CA | 29 | PTBLXML, file of 2026-04-28 | |
| Alina Silina | Needham, MA | 22 | PTBLXML, file of 2026-04-28 | |
| Jinglan Zhou | San Diego, CA | 99 | PTBLXML, file of 2026-04-28 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D513/04 | PTBLXML, file of 2026-04-28 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-04-12 | Assignment Assignment of assignor's interest | ARUMUGAM, VIJAYALAKSMI signed 2021-09-23 CLEMENS, JEREMY signed 2021-09-21 CLEVELAND, THOMAS signed 2021-09-27 FRIEMAN, BRYAN A. signed 2021-09-23 HADIDA RUAH, SARA SABINA signed 2021-09-27 MILLER, MARK THOMAS signed 2021-09-21 SILINA, ALINA signed 2021-09-26 ZHOU, JINGLAN signed 2021-09-27 | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC SAN DIEGO, CA | 63300/952 | PASDL, file of 2026-10-15 |
| 2023-04-12 | Assignment Assignment of assignor's interest | GROOTENHUIS, PETER signed 2002-10-22 | VERTEX PHARMACEUTICALS, SAN DIEGO SAN DIEGO, CA | 63300/922 | PASDL, file of 2026-10-15 |
| 2023-04-12 | Assignment Assignment of assignor's interest | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC signed 2021-10-05 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 63300/913 | PASDL, file of 2026-10-15 |
| 2023-04-12 | Assignment Assignment of assignor's interest | KRENITSKY, PAUL signed 2021-09-28 | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC SAN DIEGO, CA | 63300/889 | PASDL, file of 2026-10-15 |
| 2023-04-12 | Assignment Assignment of assignor's interest | ABELA, ALEXANDER RUSSELL signed 2021-09-27 CHAU, JACLYN signed 2021-09-21 ISHIHARA, YOSHIHIRO signed 2021-09-27 MCCARTNEY, JASON signed 2021-09-23 PIERRE, FABRICE signed 2021-09-21 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 63300/863 | PASDL, file of 2026-10-15 |
| 2023-04-12 | Assignment Assignment of assignor's interest | DWIGHT, TIMOTHY A. signed 2021-10-06 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 63300/856 | PASDL, file of 2026-10-15 |
| 2023-04-12 | Assignment Assignment of assignor's interest | ANDERSON, COREY DON signed 2021-10-05 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 63300/838 | PASDL, file of 2026-10-15 |
| 2023-04-12 | Assignment Assignment of assignor's interest | ABRAHAM, SUNNY signed 2021-09-28 | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC SAN DIEGO, CA | 63300/824 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.