Patents
US 12612409 B2: Pyrrolopyrimidines as CFTR potentiators
- Granted
- 2026-04-28
- Filed
- 2023-04-13 application 18134455
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention relates to methods of using compounds of Formula I, wherein R1a, R1b, R2, R3, R4, W, Y, and Z are as described herein, and pharmaceutically acceptable salts thereof. The compounds are potentiators of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). The invention also discloses pharmaceutical compositions comprising the compound, optionally in combination with additional therapeutic agents, and methods of potentiating, in mammals, including humans, CFTR by administration of the compounds. These compounds are useful for the treatment of cystic fibrosis (CF), asthma, bronchiectasis, chronic obstructive pulmonary disease (COPD), constipation, Diabetes mellitus, dry eye disease, pancreatitis, rhinosinusitis, Sjögren's Syndrome, and other CFTR associated disorders.
Source: PTBLXML, file of 2026-04-28 (ipgb20260428.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Cystic Fibrosis Foundation 4 patents | US company or organization | Bethesda, MD | CYSTIC FIBROSIS FOUNDATION Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-04-28 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Joseph Walter Strohbach | Wentzville, MO | 25 | PTBLXML, file of 2026-04-28 | |
| David Christopher Limburg | Salem, CT | 8 | PTBLXML, file of 2026-04-28 | |
| John Paul Mathias | Concord, MA | 17 | PTBLXML, file of 2026-04-28 | |
| Atli Thorarensen | Stow, MA | 21 | PTBLXML, file of 2026-04-28 | |
| Rajiah Aldrin Denny | Sharon, MA | 8 | PTBLXML, file of 2026-04-28 | |
| Christoph Wolfgang Zapf | Oakland, CA | 24 | PTBLXML, file of 2026-04-28 | |
| Daniel Elbaum | Newman, MA | 26 | PTBLXML, file of 2026-04-28 | |
| Lori Krim Gavrin | Villanova, PA | 12 | PTBLXML, file of 2026-04-28 | |
| Ivan Viktorovich Efremov | Chestnut, MA | 32 | PTBLXML, file of 2026-04-28 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D487/04 | PTBLXML, file of 2026-04-28 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/519 | PTBLXML, file of 2026-04-28 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P11/12 | PTBLXML, file of 2026-04-28 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-09-05 | Assignment Assignment of assignor's interest | PFIZER INC. signed 2017-10-04 | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. BETHESDA, MD | 68492/606 | PASDL, file of 2026-10-15 |
| 2024-09-05 | Assignment Assignment of assignor's interest | STROHBACH, JOSEPH WALTER signed 2017-07-19 LIMBURG, DAVID CHRISTOPHER signed 2017-08-22 MATHIAS, JOHN PAUL signed 2017-07-19 THORARENSEN, ATLI signed 2017-07-21 DENNY, RAJIAH ALDRIN signed 2017-07-20 ZAPF, CHRISTOPH WOLFGANG signed 2017-08-01 ELBAUM, DANIEL signed 2017-07-18 GAVRIN, LORI KRIM signed 2017-07-24 EFREMOV, IVAN VIKTOROVICH signed 2017-08-08 | PFIZER INC. NEW YORK, NY | 68492/592 | PASDL, file of 2026-10-15 |
| 2024-09-05 | Assignment Assignment of assignor's interest | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. signed 2019-05-29 | CYSTIC FIBROSIS FOUNDATION BETHESDA, MD | 68492/586 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.