Patents
US 12612379 B2: Inhibitors of APOL1 and methods of using same
- Granted
- 2026-04-28
- Filed
- 2022-11-29 application 18071153
- Type
- Utility · 41 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).
Source: PTBLXML, file of 2026-04-28 (ipgb20260428.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Vertex Pharmaceuticals Incorporated 764 patents | US company or organization | Boston, MA | PTBLXML, file of 2026-04-28 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Leslie A. Dakin | Framingham, MA | PTBLXML, file of 2026-04-28 | ||
| Michael A. Brodney | Newton, MA | PTBLXML, file of 2026-04-28 | ||
| Kevin B. Daniel | Boston, MA | PTBLXML, file of 2026-04-28 | ||
| Elena Dolgikh | Boston, MA | 3 | PTBLXML, file of 2026-04-28 | |
| Pedro M. Garcia Barrantes | Melrose, MA | PTBLXML, file of 2026-04-28 | ||
| Ales Medek | Winchester, MA | 24 | PTBLXML, file of 2026-04-28 | |
| Jessica H. Olsen | Jamaica Plain, MA | PTBLXML, file of 2026-04-28 | ||
| Timothy J. Senter | Arlington, MA | 9 | PTBLXML, file of 2026-04-28 | |
| Akira J. Shimizu | Framingham, MA | PTBLXML, file of 2026-04-28 | ||
| Steven D. Stone | Quincy, MA | PTBLXML, file of 2026-04-28 | ||
| Charlene Tsay | Boston, MA | PTBLXML, file of 2026-04-28 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D401/04 | PTBLXML, file of 2026-04-28 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-04-10 | Assignment Assignment of assignor's interest | DANIEL, KEVIN B. signed 2022-11-16 GARCIA BARRANTES, PEDRO M. signed 2022-11-15 MEDEK, ALES signed 2022-11-16 TSAY, CHARLENE signed 2022-11-15 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 67061/694 | PASDL, file of 2026-10-15 |
| 2024-04-10 | Assignment Assignment of assignor's interest | DAKIN, LESLIE A. signed 2022-11-15 BRODNEY, MICHAEL A. signed 2022-11-16 DOLGIKH, ELENA signed 2022-11-15 OLSEN, JESSICA H. signed 2022-11-15 SENTER, TIMOTHY J. signed 2022-11-15 SHIMIZU, AKIRA J. signed 2022-11-17 STONE, STEVEN D. signed 2022-11-15 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 67061/682 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.