Patents
US 12611464 B2: Modified clostridial neurotoxins as vaccine and conjugate vaccine platforms
- Granted
- 2026-04-28
- Filed
- 2022-10-03 application 17959272
- Type
- Utility · 16 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided herein are engineered non-catalytic, non-toxic tetanus toxin variants and methods of using such engineered tetanus toxin variants as low dose, protective vaccines that are non-toxic and more potent than their respective chemically inactivated toxoids. In addition, provided herein are conjugate vaccine carriers comprising engineered tetanus toxin variants and methods of using such conjugate vaccines to elicit T-cell dependent immune memory responses which can target a broad spectrum of microbial pathogens as a single vaccine.
Source: PTBLXML, file of 2026-04-28 (ipgb20260428.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Medical College of Wisconsin, Inc. 153 patents | US company or organization | Milwaukee, WI | THE MEDICAL COLLEGE OF WISCONSIN INC Nonprofit EXACT high confidence: identical full name and state Medical College of Wisconsin College or university FUZZY medium confidence: same name (governing-board words and legal endings aside) and state MEDICAL COLLEGE OF WISCONSIN Federal lobbying client FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-04-28 |
| Wisconsin Alumni Research Foundation 2,436 patents | US company or organization | Madison, WI | WISCONSIN ALUMNI RESEARCH FOUNDATION Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-04-28 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Joseph T. Barbieri | New Berlin, WI | 7 | PTBLXML, file of 2026-04-28 | |
| Eric A. Johnson | Madison, WI | 32 | PTBLXML, file of 2026-04-28 | |
| Sabine Pellett | Madison, WI | 12 | PTBLXML, file of 2026-04-28 | |
| William H. Tepp | Stoughton, WI | 12 | PTBLXML, file of 2026-04-28 | |
| Amanda Przedpelski | Milwaukee, WI | 3 | PTBLXML, file of 2026-04-28 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K47/6829 | PTBLXML, file of 2026-04-28 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/102 | PTBLXML, file of 2026-04-28 |
| C07K | Peptides | C07K2319/55 | PTBLXML, file of 2026-04-28 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-10-07 | Assignment Assignment of assignor's interest | JOHNSON, ERIC signed 2021-03-24 PELLETT, SABINE signed 2021-03-22 TEPP, WILLIAM signed 2021-03-22 | WISCONSIN ALUMNI RESEARCH FOUNDATION MADISON, WI | 61347/478 | PASDL, file of 2026-10-15 |
| 2022-10-04 | Assignment Assignment of assignor's interest | BARBIERI, JOSEPH T. signed 2022-10-03 PRZEDPELSKI, AMANDA signed 2022-10-04 | THE MEDICAL COLLEGE OF WISCONSIN, INC. MILWAUKEE, WI | 61298/501 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.