Patents
US 12611456 B2: Use of thiazole amide compounds for modulating human immune response
- Granted
- 2026-04-28
- Filed
- 2020-09-16 application 17761158
- Type
- Utility · 19 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided herein are thiazole amide compounds (e.g., Formula (I)) for use in enhancing human immune response and/or as adjuvants in vaccines. The compounds described herein are used as enhancers of an immune response (e.g., innate and/or adaptive immune response), and are useful in treating and/or preventing a disease, as adjuvants in a vaccine for the disease, (e.g., proliferative disease, inflammatory disease, autoimmune disease, infectious disease, or chronic disease). Also provided in the present disclosure are compositions (e.g., pharmaceutical composition), kits, methods, and uses including or using compounds described herein.
Source: PTBLXML, file of 2026-04-28 (ipgb20260428.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Children's Medical Center Corporation 717 patents | US company or organization | Boston, MA | THE CHILDREN'S MEDICAL CENTER CORPORATION State business registration FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-04-28 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| David J. Dowling | Brighton, MA | 9 | PTBLXML, file of 2026-04-28 | |
| Ofer Levy | Cambridge, MA | 30 | PTBLXML, file of 2026-04-28 | |
| Francesco Borriello | Arlington, MA | 6 | PTBLXML, file of 2026-04-28 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K39/39 | PTBLXML, file of 2026-04-28 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P37/04 | PTBLXML, file of 2026-04-28 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-07-26 | Government interest Confirmatory license | BOSTON CHILDREN'S HOSPITAL signed 2022-05-25 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT BETHESDA, MD | 64396/537 | PASDL, file of 2026-10-15 |
| 2022-04-12 | Assignment Assignment of assignor's interest | DOWLING, DAVID J. signed 2021-12-22 LEVY, OFER signed 2021-12-22 BORRIELLO, FRANCESCO signed 2021-12-22 | CHILDREN'S MEDICAL CENTER CORPORATION BOSTON, MA | 59568/985 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.