Patents
US 12605429 B2: Proteins having pneumococcal capsule degrading activity and methods of use
- Granted
- 2026-04-21
- Filed
- 2023-05-19 application 18199685
- Type
- Utility · 19 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided herein is a protein, referred to as a Pn3Pase protein, that degrades the capsular polysaccharide of serotype 3 Streptococcus pneumoniae. The disclosure includes a genetically modified cell that includes a Pn3Pase protein, and compositions that include the protein, the polynucleotide encoding the protein, the genetically modified cell, or a combination thereof. Also provided are methods for using a Pn3Pase protein, including methods for contacting a S. pneumoniae having a type III capsular polysaccharide with a Pn3Pase protein, increasing deposition of at least one complement component on the surface of a S. pneumoniae, treating an infection in a subject, treating a symptom in a subject, decreasing colonization of a subject by S. pneumoniae, or a combination thereof.
Source: PTBLXML, file of 2026-04-21 (ipgb20260421.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. 535 patents | US company or organization | Athens, GA | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. State business registration EXACT high confidence: identical full name and state UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-04-21 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Fikri Y. Avci | Watkinsville, GA | 4 | PTBLXML, file of 2026-04-21 | |
| Dustin Middleton | Athens, GA | 2 | PTBLXML, file of 2026-04-21 | |
| Amy Victoria Paschall | Washington, GA | 2 | PTBLXML, file of 2026-04-21 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/47 | PTBLXML, file of 2026-04-21 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P31/04 | PTBLXML, file of 2026-04-21 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N1/20 | PTBLXML, file of 2026-04-21 |
| C12Y | Enzymes | C12Y302/01031 | PTBLXML, file of 2026-04-21 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.