Patents
US 12583917 B2: IL17A antibodies and antagonists for veterinary use
- Granted
- 2026-03-24
- Filed
- 2022-03-04 application 17687083
- Type
- Utility · 16 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided are various embodiments relating to anti-IL17A antibodies and IL17Ra ECD polypeptides that bind to IL17A. In various embodiments, such anti-IL17A antibodies or IL17Ra ECD polypeptides can be used in methods to treat IL17-induced conditions in subjects, such as humans or companion animals, such as canines, felines, and equines. Also provided are various embodiments relating to IgG Fc variant polypeptides having one or more amino acid substitutions for reducing binding to C1q and/or CD16. In some embodiments, the IgG Fc variants and/or polypeptides comprising the IgG Fc variants (e.g., fusion polypeptides comprising the IgG Fc variants and the anti-IL17A antibodies and/or IL17Ra ECD polypeptides described herein) may have reduced complement-mediated immune responses and/or antibody-dependent cell-mediated cytotoxicity.
Source: PTBLXML, file of 2026-03-24 (ipgb20260324.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Elanco US Inc. 52 patents | US company or organization | Greenfield, IN | PTBLXML, file of 2026-03-24 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Shyr Jiann Li | Millbrae, CA | 18 | PTBLXML, file of 2026-03-24 | |
| Lam Nguyen | Union City, CA | 30 | PTBLXML, file of 2026-03-24 | |
| Lan Yang | Union City, CA | PTBLXML, file of 2026-03-24 | ||
| Hangjun Zhan | Foster City, CA | 17 | PTBLXML, file of 2026-03-24 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K16/244 | PTBLXML, file of 2026-03-24 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K39/3955 | PTBLXML, file of 2026-03-24 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/63 | PTBLXML, file of 2026-03-24 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-10-02 | Merger Merger and change of name | KINDRED BIOSCIENCES, INC. signed 2022-03-24 ELANCO US INC. signed 2022-03-24 | ELANCO US INC. GREENFIELD, IN | 65091/55 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.