Patents
US 12571046 B2: Methods of detecting and treating multiple system atrophy
- Granted
- 2026-03-10
- Filed
- 2021-05-28 application 17334683
- Type
- Utility · 13 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure relates to a method for diagnosing and treating multiple-system atrophy (MSA) in a subject, the method comprising: determining in a subject-derived biological sample an expression level of a gene from the group consisting of: QKI, GGCX, MOCS1, NF1, LINC01572, PRRG3, HMBOX1, PLP1, PPP1CA, C8orf88, TGFB2, MASP1, TIAM1, SYNGAP1, ACTN1, EMP1, NFIL3, GPNMB, PGAM2, ST5, STON1, RFTN1, and MMP14; comparing the subject-derived expression level of the gene with a normal control expression level of the gene obtained from a non-neurodegenerative biological sample; diagnosing the subject as a having MSA by detecting a differential expression of the gene in the subject-derived biological sample as compared to the normal control expression level; and administering a peroxisome proliferator-activated receptor β (PPARβ) agonist or a retinoid X receptor (RXR) agonist to the subject diagnosed as having MSA.
Source: PTBLXML, file of 2026-03-10 (ipgb20260310.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE 123 patents | US company or organization | Phoenix, AZ | Translational Genomics Research Institute State business registration FUZZY medium confidence: same name (legal endings aside) and state TRANSLATIONAL GENOMICS RESEARCH INSTITUTE Federal lobbying client FUZZY medium confidence: same name (legal endings aside) and state TRANSLATIONAL GENOMICS RESEARCH INSTITUTE Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-03-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Matthew J. Huentelman | Phoenix, AZ | PTBLXML, file of 2026-03-10 | ||
| Ignazio Piras | Phoenix, AZ | PTBLXML, file of 2026-03-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/6883 | PTBLXML, file of 2026-03-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/192 | PTBLXML, file of 2026-03-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P25/28 | PTBLXML, file of 2026-03-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.